Acute histologic inflammatory activity and postoperative outcomes in pediatric patients with ulcerative colitis.
Adolescent
Cohort Studies
Colitis, Ulcerative
/ pathology
Colonic Pouches
Eosinophils
/ pathology
Fecal Incontinence
/ etiology
Female
Humans
Intestinal Fistula
/ etiology
Intestinal Mucosa
/ pathology
Intestinal Obstruction
/ etiology
Leukocytes, Mononuclear
/ pathology
Male
Neutrophils
/ pathology
Postoperative Complications
Pouchitis
/ etiology
Proctocolectomy, Restorative
Rectum
/ pathology
Retrospective Studies
Geboes score
Ileal pouch anal anastomosis
J-pouch
Total proctocolectomy
Ulcerative colitis
Journal
American journal of surgery
ISSN: 1879-1883
Titre abrégé: Am J Surg
Pays: United States
ID NLM: 0370473
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
08
08
2017
revised:
23
10
2019
accepted:
27
02
2020
pubmed:
27
3
2020
medline:
12
5
2020
entrez:
27
3
2020
Statut:
ppublish
Résumé
The aim of this study was to determine whether acute histologic inflammatory activity at the rectal margin predicts postoperative complications in children with ulcerative colitis following ileal pouch-anal anastomoses (IPAA). Patients who underwent IPAA following previous total abdominal colectomy for ulcerative colitis between 2006 and 2014 were included. Data collected included demographics, operative and postoperative data, histologic grading of the rectal margin at time of IPAA, and stooling outcomes at one, six and 12 months following ileostomy closure. Twenty-seven patients were included. Acute inflammation scores ranged between 2 and 13. Unadjusted and adjusted models showed no statistically significant relationship between inflammation and presence of any postoperative complications, number of daily stools, nighttime stooling, soiling, or stool-altering medication usage. Acute histologic inflammatory activity at the rectal margin is not associated with increased rates of postoperative complications following IPAA creation in children, nor with poorer continence outcomes following ileostomy closure.
Sections du résumé
BACKGROUND
The aim of this study was to determine whether acute histologic inflammatory activity at the rectal margin predicts postoperative complications in children with ulcerative colitis following ileal pouch-anal anastomoses (IPAA).
METHODS
Patients who underwent IPAA following previous total abdominal colectomy for ulcerative colitis between 2006 and 2014 were included. Data collected included demographics, operative and postoperative data, histologic grading of the rectal margin at time of IPAA, and stooling outcomes at one, six and 12 months following ileostomy closure.
RESULTS
Twenty-seven patients were included. Acute inflammation scores ranged between 2 and 13. Unadjusted and adjusted models showed no statistically significant relationship between inflammation and presence of any postoperative complications, number of daily stools, nighttime stooling, soiling, or stool-altering medication usage.
CONCLUSION
Acute histologic inflammatory activity at the rectal margin is not associated with increased rates of postoperative complications following IPAA creation in children, nor with poorer continence outcomes following ileostomy closure.
Identifiants
pubmed: 32209240
pii: S0002-9610(20)30135-5
doi: 10.1016/j.amjsurg.2020.02.054
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
592-597Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.