Role of Histone Deacetylases in Carcinogenesis: Potential Role in Cholangiocarcinoma.
HDACi
HDACs
cholangiocarcinoma
hepatobiliary cancers
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
23 03 2020
23 03 2020
Historique:
received:
05
02
2020
revised:
05
03
2020
accepted:
17
03
2020
entrez:
27
3
2020
pubmed:
27
3
2020
medline:
11
2
2021
Statut:
epublish
Résumé
Cholangiocarcinoma (CCA) is a highly invasive and metastatic form of carcinoma with bleak prognosis due to limited therapies, frequent relapse, and chemotherapy resistance. There is an urgent need to identify the molecular regulators of CCA in order to develop novel therapeutics and advance diseases diagnosis. Many cellular proteins including histones may undergo a series of enzyme-mediated post-translational modifications including acetylation, methylation, phosphorylation, sumoylation, and crotonylation. Histone deacetylases (HDACs) play an important role in regulating epigenetic maintenance and modifications of their targets, which in turn exert critical impacts on chromatin structure, gene expression, and stability of proteins. As such, HDACs constitute a group of potential therapeutic targets for CCA. The aim of this review was to summarize the role that HDACs perform in regulating epigenetic changes, tumor development, and their potential as therapeutic targets for CCA.
Identifiants
pubmed: 32210140
pii: cells9030780
doi: 10.3390/cells9030780
pmc: PMC7140894
pii:
doi:
Substances chimiques
Biological Products
0
Histone Deacetylases
EC 3.5.1.98
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : R01 CA183764
Pays : United States
Références
Handb Exp Pharmacol. 2011;206:39-56
pubmed: 21879445
Adv Exp Med Biol. 2008;615:261-98
pubmed: 18437899
Oncotarget. 2016 Mar 1;7(9):9975-92
pubmed: 26862738
Mol Cell Biol. 2015 Oct;35(20):3547-65
pubmed: 26240284
Biochim Biophys Acta. 2005 Sep 30;1745(3):318-29
pubmed: 16109447
Oncogene. 2012 Feb 2;31(5):583-94
pubmed: 21685935
Oncogene. 2004 Jan 8;23(1):21-9
pubmed: 14712207
Can J Cardiol. 2016 May;32(5):634-41
pubmed: 26948035
J Clin Invest. 2013 Dec;123(12):5212-30
pubmed: 24200693
Bioorg Med Chem. 2017 Jun 15;25(12):3077-3086
pubmed: 28416100
Cell Death Differ. 2012 Jul;19(7):1239-52
pubmed: 22301920
Asian Pac J Cancer Prev. 2013;14(4):2503-8
pubmed: 23725164
Redox Biol. 2017 Aug;12:340-349
pubmed: 28288414
J Hepatol. 2017 Feb;66(2):424-441
pubmed: 27686679
Antioxid Redox Signal. 2015 Jul 1;23(1):30-50
pubmed: 24483782
J Hepatol. 2012 Jul;57(1):84-91
pubmed: 22326466
Curr Top Med Chem. 2019;19(3):223-241
pubmed: 30674261
Cold Spring Harb Perspect Biol. 2014 Apr 01;6(4):a018713
pubmed: 24691964
Mol Oncol. 2014 Dec;8(8):1379-92
pubmed: 24954856
Gastroenterology. 2009 Jul;137(1):361-71, 371.e1-5
pubmed: 19362090
J Cell Biochem. 2012 Jun;113(6):2167-77
pubmed: 22492270
Curr Opin Struct Biol. 2018 Dec;53:169-177
pubmed: 30391813
Biomed Pharmacother. 2018 Feb;98:233-241
pubmed: 29268244
Science. 2013 Jan 11;339(6116):211-4
pubmed: 23223453
Adv Clin Chem. 2011;53:155-77
pubmed: 21404918
Oncotarget. 2014 Aug 15;5(15):5893-907
pubmed: 25071017
Cancer Discov. 2014 Dec;4(12):1387-97
pubmed: 25266735
Int J Mol Sci. 2017 Aug 31;18(9):
pubmed: 30563957
J Gastrointest Surg. 2003 Nov;7(7):864-70
pubmed: 14592659
Cancer Res. 2013 Apr 1;73(7):2259-70
pubmed: 23370327
Annu Rev Nutr. 2008;28:347-66
pubmed: 18598138
Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1649-54
pubmed: 22307625
Front Biosci (Schol Ed). 2012 Jan 01;4:831-9
pubmed: 22202094
PLoS One. 2014 Jun 04;9(6):e98894
pubmed: 24896240
Mol Cancer Res. 2013 Jan;11(1):62-73
pubmed: 23175521
Cancer Sci. 2010 Feb;101(2):355-62
pubmed: 19860841
Mol Oncol. 2007 Jun;1(1):19-25
pubmed: 19383284
Nat Rev Clin Oncol. 2018 Feb;15(2):95-111
pubmed: 28994423
Med Oncol. 2015 Jan;32(1):390
pubmed: 25452172
EMBO Rep. 2015 Jun;16(6):689-99
pubmed: 25870236
Annu Rev Biochem. 2007;76:75-100
pubmed: 17362198
Semin Liver Dis. 2014 Nov;34(4):456-64
pubmed: 25369307
Curr Drug Targets. 2017;18(8):950-957
pubmed: 25915482
PLoS One. 2012;7(11):e49062
pubmed: 23139833
Front Pharmacol. 2012 Jan 31;3:4
pubmed: 22319497
Nutrients. 2014 Oct 15;6(10):4273-301
pubmed: 25322459
J Mol Med (Berl). 2013 Jan;91(1):49-58
pubmed: 22763818
Oncol Rep. 2015 Apr;33(4):1976-84
pubmed: 25682960
Genes Cancer. 2013 Mar;4(3-4):112-7
pubmed: 24020002
Eur J Med Chem. 2019 Jan 1;161:48-77
pubmed: 30342425
Mol Cell. 2012 Nov 30;48(4):612-26
pubmed: 23063526
PLoS One. 2011;6(7):e22264
pubmed: 21789245
Gut Microbes. 2016 May 3;7(3):189-200
pubmed: 26963409
Gut. 2012 Mar;61(3):439-48
pubmed: 22147512
Genes Dev. 2006 Sep 15;20(18):2566-79
pubmed: 16980585
J Biol Chem. 2012 Sep 14;287(38):32006-16
pubmed: 22822071
Am J Pathol. 2014 Mar;184(3):600-8
pubmed: 24434010
Science. 2009 Sep 4;325(5945):1254-7
pubmed: 19729656
PLoS One. 2015 Aug 19;10(8):e0136193
pubmed: 26287365
Oncol Lett. 2019 Mar;17(3):3041-3047
pubmed: 30867732
Chem Biol Interact. 2017 Aug 1;273:99-106
pubmed: 28600122
Cell Death Dis. 2017 Jun 1;8(6):e2856
pubmed: 28569784
Nutrients. 2018 Jun 06;10(6):
pubmed: 29882797
Sci Rep. 2015 Aug 06;5:12917
pubmed: 26246421
Int J Cancer. 2005 Apr 20;114(4):513-21
pubmed: 15609335
Am J Pathol. 2018 Apr;188(4):981-994
pubmed: 29366679
Cells. 2015 Apr 23;4(2):135-68
pubmed: 25915736
Hepatology. 2019 Apr;69(4):1582-1598
pubmed: 30299561
Nucleic Acids Res. 2012 Jun;40(11):4794-803
pubmed: 22323521
Biosci Rep. 1994 Dec;14(6):291-300
pubmed: 7620080
Neoplasia. 2019 May;21(5):429-441
pubmed: 30933885
Hepatology. 2018 Aug;68(2):561-573
pubmed: 29406621
Mol Carcinog. 2019 Apr;58(4):524-532
pubmed: 30501014
Dig Dis Sci. 2017 Aug;62(8):1872-1880
pubmed: 28527050
Nat Rev Cancer. 2018 Aug;18(8):511-524
pubmed: 29802351
Curr Drug Targets. 2017;18(8):958-963
pubmed: 25706257
Trends Mol Med. 2010 Nov;16(11):528-36
pubmed: 20932800
Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1245-1253
pubmed: 28625917
Histol Histopathol. 2008 Apr;23(4):487-96
pubmed: 18228206
Mol Cell. 2013 Jan 24;49(2):310-21
pubmed: 23201122
Nature. 1998 Feb 5;391(6667):597-601
pubmed: 9468139
Biochem J. 2009 Jan 1;417(1):379-89
pubmed: 18789002
Adv Biomed Res. 2019 Oct 31;8:63
pubmed: 31737580
Hepatology. 2008 Jul;48(1):308-21
pubmed: 18536057
Int J Oncol. 2016 Jan;48(1):409-20
pubmed: 26575528
Oncogene. 2012 Oct 25;31(43):4619-29
pubmed: 22249256
EMBO Rep. 2017 Feb;18(2):334-343
pubmed: 28028031
Nature. 2002 May 23;417(6887):455-8
pubmed: 12024216
Adv Sci (Weinh). 2018 Nov 16;6(1):1801138
pubmed: 30643718
Sci Rep. 2017 Sep 7;7(1):10921
pubmed: 28883618
Int J Mol Sci. 2017 Jul 01;18(7):
pubmed: 28671573
Chem Soc Rev. 2015 Aug 7;44(15):5246-64
pubmed: 25955411
Int J Mol Med. 2013 Apr;31(4):967-74
pubmed: 23440283