Iron bioavailability from bouillon fortified with a novel ferric phytate compound: a stable iron isotope study in healthy women (part II).
Adult
Caco-2 Cells
Cross-Over Studies
Female
Ferric Compounds
/ chemistry
Ferritins
/ blood
Food, Fortified
Humans
Hydrolysis
Iron
/ pharmacokinetics
Iron Radioisotopes
/ pharmacokinetics
Phytic Acid
/ chemistry
Plant Proteins, Dietary
/ chemistry
Single-Blind Method
Young Adult
Zea mays
/ chemistry
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 03 2020
24 03 2020
Historique:
received:
16
08
2019
accepted:
04
03
2020
entrez:
27
3
2020
pubmed:
27
3
2020
medline:
19
12
2020
Statut:
epublish
Résumé
Bouillon cubes are widely consumed and when fortified with iron could contribute in preventing iron deficiency. We report the development (part I) and evaluation (current part II) of a novel ferric phytate compound to be used as iron fortificant in condiments such as bouillon. Ferric pyrophosphate (FePP), is the compound of choice due to its high stability in foods, but has a modest absorption in humans. Our objective was to assess iron bioavailability from a novel iron fortificant consisting of ferric iron complexed with phytic acid and hydrolyzed corn protein (Fe-PA-HCP), used in bouillon with and without an inhibitory food matrix. In a randomised single blind, cross-over study, we measured iron absorption in healthy adult women (n = 22). In vitro iron bioaccessibility was assessed using a Caco-2 cell model. Iron absorption from Fe-PA-HCP was 1.5% and 4.1% in bouillon with and without inhibitory matrix, respectively. Relative iron bioavailability to FeSO
Identifiants
pubmed: 32210349
doi: 10.1038/s41598-020-62307-1
pii: 10.1038/s41598-020-62307-1
pmc: PMC7093532
doi:
Substances chimiques
Ferric Compounds
0
Iron Radioisotopes
0
Iron-54
0
Plant Proteins, Dietary
0
Phytic Acid
7IGF0S7R8I
Ferritins
9007-73-2
Iron
E1UOL152H7
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
5339Références
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