The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia.
Adult
Aminopeptidases
/ genetics
Cells, Cultured
Cytokines
/ metabolism
Female
Gene Expression Regulation
Humans
Leukocytes, Mononuclear
/ immunology
Lymphocyte Activation
Minor Histocompatibility Antigens
/ genetics
Placenta
/ metabolism
Placentation
Pre-Eclampsia
/ genetics
Pregnancy
Trophoblasts
/ metabolism
first trimester
hypertension in pregnancy
immunology
placenta
trophoblast
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
10
2019
accepted:
19
02
2020
entrez:
27
3
2020
pubmed:
27
3
2020
medline:
16
3
2021
Statut:
epublish
Résumé
Pre-eclampsia (PE) is a disorder of pregnancy, often leading to serious and fatal complications. Endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1/ERAP2) are present in the placenta. They are involved in processes regulating blood pressure, angiogenesis, cytokine receptor shedding, and immune recognition. Previous studies have associated both ERAP1/ERAP2 genetic variants with PE, although the underlying mechanisms remain unknown. Less is known about the roles for these enzymes in early placentation, which could be a contributory factor to PE. To ascertain whether ERAP1/ERAP2 change in PE and whether such a change is present before PE is clinically diagnosed, we analyzed mRNA and ERAP1/2 protein expression in the placenta in the early first trimester (8-14 weeks) and at delivery in normotensive or PE women (
Identifiants
pubmed: 32210971
doi: 10.3389/fimmu.2020.00396
pmc: PMC7076169
doi:
Substances chimiques
Cytokines
0
Minor Histocompatibility Antigens
0
Aminopeptidases
EC 3.4.11.-
ERAP1 protein, human
EC 3.4.11.-
ERAP2 protein, human
EC 3.4.11.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
396Subventions
Organisme : NCI NIH HHS
ID : P30 CA016059
Pays : United States
Organisme : NINDS NIH HHS
ID : P30 NS047463
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD073555
Pays : United States
Organisme : British Heart Foundation
ID : FS/15/32/31604
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Seamon, Kurlak, Warthan, Stratikos, Strauss, Mistry and Lee.
Références
J Physiol. 2016 Mar 1;594(5):1327-40
pubmed: 26574162
Placenta. 2010 May;31(5):448-55
pubmed: 20304486
Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19890-5
pubmed: 24248368
J Biochem. 2000 Nov;128(5):755-62
pubmed: 11056387
Best Pract Res Clin Obstet Gynaecol. 2011 Aug;25(4):405-17
pubmed: 21429808
Placenta. 2013 Feb;34(2):182-6
pubmed: 23246097
Hypertens Pregnancy. 2008;27(4):396-405
pubmed: 19003640
Cancer Res. 2015 Mar 1;75(5):824-34
pubmed: 25592150
Obstet Gynecol Annu. 1972;1:177-91
pubmed: 4669123
Hypertens Pregnancy. 2001;20(1):IX-XIV
pubmed: 12044323
Trends Immunol. 2006 Sep;27(9):399-404
pubmed: 16843067
J Hum Hypertens. 2014 Oct;28(10):610-6
pubmed: 24804790
Int J Mol Sci. 2012;13(7):8338-52
pubmed: 22942706
J Reprod Immunol. 2003 Aug;59(2):161-73
pubmed: 12896820
J Lipid Res. 2013 Oct;54(10):2658-64
pubmed: 23898049
Hypertension. 2008 Nov;52(5):881-8
pubmed: 18852388
Mol Cell. 2015 Jun 18;58(6):1015-27
pubmed: 25959394
Hum Genet. 2009 Nov;126(5):655-66
pubmed: 19578876
Placenta. 2014 Feb;35(2):117-24
pubmed: 24331737
BMC Med Genet. 2011 May 11;12:64
pubmed: 21569342
Biol Reprod. 2018 Mar 1;98(3):309-322
pubmed: 29324974
Hypertension. 2011 Sep;58(3):497-504
pubmed: 21730298