Targeting HER2 with Trastuzumab Deruxtecan: A Dose-Expansion, Phase I Study in Multiple Advanced Solid Tumors.
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
21
10
2019
revised:
23
01
2020
accepted:
17
02
2020
pubmed:
28
3
2020
medline:
16
11
2021
entrez:
28
3
2020
Statut:
ppublish
Résumé
HER2-targeted therapies are approved only for HER2-positive breast and gastric cancers. We assessed the safety/tolerability and activity of the novel HER2-targeted antibody-drug conjugate trastuzumab deruxtecan (T-DXd) in 60 patients with pretreated, HER2-expressing (IHC ≥ 1+), non-breast/non-gastric or
Identifiants
pubmed: 32213540
pii: 2159-8290.CD-19-1014
doi: 10.1158/2159-8290.CD-19-1014
pmc: PMC8292921
mid: NIHMS1723894
doi:
Substances chimiques
Immunoconjugates
0
trastuzumab deruxtecan
5384HK7574
Receptor, ErbB-2
EC 2.7.10.1
Trastuzumab
P188ANX8CK
Camptothecin
XT3Z54Z28A
Types de publication
Clinical Trial, Phase I
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
688-701Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
©2020 American Association for Cancer Research.
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