Reduction in the Number of Varicella-Zoster Virus-Specific T-Cells in Immunocompromised Children with Varicella.
Antigens, CD
/ metabolism
Antigens, Differentiation, T-Lymphocyte
/ metabolism
Chickenpox
/ drug therapy
Child
Child, Preschool
Convalescence
Herpesvirus 3, Human
/ immunology
Humans
Immunocompetence
Immunosuppressive Agents
/ therapeutic use
Infant
Interferon-gamma
/ metabolism
Lectins, C-Type
/ metabolism
Lymphocyte Activation
/ immunology
Lymphocyte Count
Species Specificity
T-Lymphocytes
/ immunology
Tissue Donors
cellular immunity
chickenpox
immunosuppressive agents
interferon-gamma
varicella-zoster virus
Journal
The Tohoku journal of experimental medicine
ISSN: 1349-3329
Titre abrégé: Tohoku J Exp Med
Pays: Japan
ID NLM: 0417355
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
entrez:
28
3
2020
pubmed:
28
3
2020
medline:
19
12
2020
Statut:
ppublish
Résumé
Varicella zoster virus (VZV) causes a life-threatening infection in immunocompromised hosts. The immune response to VZV of healthy subjects has been rigorously assessed, but little is known about that of immunocompromised individuals. This study aimed to clarify the primary response to VZV infection in immunocompromised children. This prospective study enrolled six immunocompromised children (median age, 33 months; range, 20-62) receiving steroids or immunosuppressants, and 10 immunocompetent children (median age, 32 months; range, 15-81) with varicella. The immunocompromised children were three patients with acute lymphoblastic leukemia, two recipients with liver transplantation and one patient with juvenile idiopathic arthritis. Interferon-γ-producing CD69
Identifiants
pubmed: 32213753
doi: 10.1620/tjem.250.181
doi:
Substances chimiques
Antigens, CD
0
Antigens, Differentiation, T-Lymphocyte
0
CD69 antigen
0
Immunosuppressive Agents
0
Lectins, C-Type
0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM