Housing temperature influences exercise training adaptations in mice.
Adaptation, Physiological
/ physiology
Adipose Tissue
/ drug effects
Animals
Body Composition
Energy Metabolism
Female
Gastrointestinal Microbiome
Housing, Animal
Insulin
/ pharmacology
Mice
Mice, Inbred C57BL
Muscle, Skeletal
/ drug effects
Physical Conditioning, Animal
/ physiology
Stress, Physiological
Temperature
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
25 03 2020
25 03 2020
Historique:
received:
23
05
2019
accepted:
27
02
2020
entrez:
28
3
2020
pubmed:
28
3
2020
medline:
15
7
2020
Statut:
epublish
Résumé
Exercise training is a powerful means to combat metabolic diseases. Mice are extensively used to investigate the benefits of exercise, but mild cold stress induced by ambient housing temperatures may confound translation to humans. Thermoneutral housing is a strategy to make mice more metabolically similar to humans but its effects on exercise adaptations are unknown. Here we show that thermoneutral housing blunts exercise-induced improvements in insulin action in muscle and adipose tissue and reduces the effects of training on energy expenditure, body composition, and muscle and adipose tissue protein expressions. Thus, many reported effects of exercise training in mice are likely secondary to metabolic stress of ambient housing temperature, making it challenging to translate to humans. We conclude that adaptations to exercise training in mice critically depend upon housing temperature. Our findings underscore housing temperature as a critical parameter in the design and interpretation of murine exercise training studies.
Identifiants
pubmed: 32214091
doi: 10.1038/s41467-020-15311-y
pii: 10.1038/s41467-020-15311-y
pmc: PMC7096511
doi:
Substances chimiques
Insulin
0
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1560Références
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