Osmotic and hypoxic induction of osteopontin in retinal pigment epithelial cells: Involvement of purinergic receptor signaling.
Adenosine Triphosphate
/ pharmacology
CREB-Binding Protein
/ genetics
Cell Hypoxia
/ drug effects
Cells, Cultured
Epithelial Cells
/ drug effects
Fibroblast Growth Factors
/ genetics
Gene Expression Regulation
/ drug effects
Humans
Osmotic Pressure
/ drug effects
Osteopontin
/ genetics
Phosphatidylinositol 3-Kinases
/ metabolism
Phospholipases A2
/ metabolism
Purinergic Agonists
/ pharmacology
RNA, Small Interfering
Receptors, Purinergic
/ metabolism
Retina
/ metabolism
Retinal Pigment Epithelium
/ cytology
Signal Transduction
/ drug effects
Sodium Chloride
/ pharmacology
Transcription Factors
/ genetics
Vascular Endothelial Growth Factor A
/ metabolism
p38 Mitogen-Activated Protein Kinases
/ metabolism
Journal
Molecular vision
ISSN: 1090-0535
Titre abrégé: Mol Vis
Pays: United States
ID NLM: 9605351
Informations de publication
Date de publication:
2020
2020
Historique:
received:
14
05
2019
accepted:
06
03
2020
entrez:
28
3
2020
pubmed:
28
3
2020
medline:
5
2
2021
Statut:
epublish
Résumé
Osteopontin (OPN) is a neuroprotective factor in the retina that improves photoreceptor survival. The aim of the present study was to investigate whether human RPE cells express and respond to OPN. Hypoxia and chemical hypoxia were induced by cell culture in 0.25% O The acutely isolated RPE cells and the cultured RPE cells expressed The data indicated that RPE cells produce and respond to OPN;
Substances chimiques
NFAT5 protein, human
0
Purinergic Agonists
0
RNA, Small Interfering
0
Receptors, Purinergic
0
Transcription Factors
0
VEGFA protein, human
0
Vascular Endothelial Growth Factor A
0
Osteopontin
106441-73-0
fibroblast growth factor 13
330E71H5Q4
Sodium Chloride
451W47IQ8X
Fibroblast Growth Factors
62031-54-3
Adenosine Triphosphate
8L70Q75FXE
CREB-Binding Protein
EC 2.3.1.48
CREBBP protein, human
EC 2.3.1.48
p38 Mitogen-Activated Protein Kinases
EC 2.7.11.24
Phospholipases A2
EC 3.1.1.4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
188-203Informations de copyright
Copyright © 2020 Molecular Vision.
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