FSH for the Treatment of Male Infertility.
FSH
biosimilars
gonadotropin
male infertility
testis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Mar 2020
25 Mar 2020
Historique:
received:
02
03
2020
revised:
22
03
2020
accepted:
24
03
2020
entrez:
29
3
2020
pubmed:
29
3
2020
medline:
9
4
2020
Statut:
epublish
Résumé
Follicle-stimulating hormone (FSH) supports spermatogenesis acting via its receptor (FSHR), which activates trophic effects in gonadal Sertoli cells. These pathways are targeted by hormonal drugs used for clinical treatment of infertile men, mainly belonging to sub-groups defined as hypogonadotropic hypogonadism or idiopathic infertility. While, in the first case, fertility may be efficiently restored by specific treatments, such as pulsatile gonadotropin releasing hormone (GnRH) or choriogonadotropin (hCG) alone or in combination with FSH, less is known about the efficacy of FSH in supporting the treatment of male idiopathic infertility. This review focuses on the role of FSH in the clinical approach to male reproduction, addressing the state-of-the-art from the little data available and discussing the pharmacological evidence. New compounds, such as allosteric ligands, dually active, chimeric gonadotropins and immunoglobulins, may represent interesting avenues for future personalized, pharmacological approaches to male infertility.
Identifiants
pubmed: 32218314
pii: ijms21072270
doi: 10.3390/ijms21072270
pmc: PMC7177393
pii:
doi:
Substances chimiques
Follicle Stimulating Hormone
9002-68-0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Commission
ID : Skłodowska-Curie grant No 665790
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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