Glucocorticoids Influencing Wnt/β-Catenin Pathway; Multiple Sites, Heterogeneous Effects.
Wnt/β-catenin pathway
adipose tissue
bone
brain
glucocorticoid excess
skin
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
25 Mar 2020
25 Mar 2020
Historique:
received:
19
02
2020
revised:
17
03
2020
accepted:
23
03
2020
entrez:
29
3
2020
pubmed:
29
3
2020
medline:
17
12
2020
Statut:
epublish
Résumé
Glucocorticoid hormones are vital; their accurate operation is a necessity at all ages and in all life situations. Glucocorticoids regulate diverse physiological processes and they use many signaling pathways to fulfill their effect. As the operation of these hormones affects many organs, the excess of glucocorticoids is actually detrimental to the whole human body. The endogenous glucocorticoid excess is a relatively rare condition, but a significant proportion of adult people uses glucocorticoid medication for the treatment of chronic illnesses, therefore they are exposed to the side effects of long-term glucocorticoid treatment. Our review summarizes the adverse effects of glucocorticoid excess affecting bones, adipose tissue, brain and skin, focusing on those effects which involve the Wnt/β-catenin pathway.
Identifiants
pubmed: 32218328
pii: molecules25071489
doi: 10.3390/molecules25071489
pmc: PMC7181001
pii:
doi:
Substances chimiques
Glucocorticoids
0
beta Catenin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Institute of Research and Innovation Ministry Hungary
ID : TUDFO/51757/2019-ITM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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