Preparation and separation of epothilones with anticancer activity.
Antineoplastic Agents
/ chemical synthesis
Apoptosis
/ drug effects
Cell Line, Tumor
Cell Proliferation
/ drug effects
Ceramics
/ chemistry
Drug Screening Assays, Antitumor
Epothilones
/ biosynthesis
Fermentation
Glycosylation
Humans
Mutation
Porosity
Secondary Metabolism
Streptomyces
/ genetics
Structure-Activity Relationship
Surface Properties
epothilones
separation
synthesis
yield
Journal
Chemical biology & drug design
ISSN: 1747-0285
Titre abrégé: Chem Biol Drug Des
Pays: England
ID NLM: 101262549
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
02
08
2019
revised:
20
11
2019
accepted:
13
03
2020
pubmed:
29
3
2020
medline:
23
6
2021
entrez:
29
3
2020
Statut:
ppublish
Résumé
Epothilone is a kind of macrolide compound, which has anticancer activity and strong inhibitory effect on breast cancer and rectal cancer cells. Herein, the chemical and biological synthesis of epothilones and how to improve fermentation yield and separation methods were summarized and discussed.
Substances chimiques
Antineoplastic Agents
0
Epothilones
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
785-789Informations de copyright
© 2020 John Wiley & Sons A/S.
Références
Bian, X., Tang, B., Yu, Y., Tu, Q., Gross, F., Wang, H., …Zhang, Y. (2017). Heterologous production and yields improvement of epothilones in the Burkholderiales strain DSM 7029. ACS Chemical Biology, 12, 1805-1812.
Bollag, D. M., Mcqueney, P. A., Zhu, J., Hensens, O., Koupal, L., Liesch, J., … Woods, C. M. (1995). Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Research, 55, 2325-2333.
Cheng, H., & Huang, G. (2018). Synthesis & antitumor activity of epothilones B and D and their analogs. Future Medicinal Chemistry, 10(12), 1483-1496.
Cheng, H., & Huang, G. (2018). Synthesis and activity of epothilone D. Current Drug Targets, 19(15), 1866-1870.
Cheng, H., Huang, H., & Huang, G. (2018). Synthesis and antitumor activity of epothilone B. European Journal of Medicinal Chemistry, 157, 925-934.
Christian, F. J. (2015). Transposon-assisted genetic engineering with mos1-mediated single-copy insertion (MosSCI). Methods in Molecular Biology, 1327, 49-58.
Fornier, M. N. (2007). Epothilones in breast cancer: Review of clinical experience. Annals of Oncology, 18(s5), v16-v21.
Fu, J., Wenzel, S. C., Perlova, O., Wang, J., Gross, F., Tang, Z., … Zhang, Y. (2008). Efficient transfer of two large secondary metabolite pathway gene clusters into heterologous hosts by transposition. Nucleic Acids Research, 36, e113.
Gao, H., & Huang, G. (2018). Synthesis, anticancer activity and cytotoxicity of galactosylated epothilone B. Bioorganic and Medicinal Chemistry, 26(20), 5578-5581.
Gerth, K., Bedorf, N., Höfle, G., Irschik, H., & Reichenbach, H. (1996). Epothilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties. The Journal of Antibiotics, 49, 560-563.
Han, K., Li, Z.-F., Peng, R., Zhu, L.-P., Zhou, T., Wang, L.-G., … Li, Y.-Z. (2013). Extraordinary expansion of a Sorangium cellulosum genome from an alkaline milieu. Scientific Reports, 3, 2101.
Hardt, I. H., Steinmetz, H., Gerth, K., Sasse, F., Reichenbach, H., & Höfle, G. (2001). New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: Isolation, structure elucidation, and SAR studies. Journal of Natural Products, 64(7), 847-856.
Huang, S., & Huang, G. (2019). Synthesis, anticancer activity and cytotoxicity of 7-O-β-D-galactosyl-polyethylene glycol-epothilone B. Chemical Biology & Drug Design, 93, 539-543.
Li, S. G., Zhao, L., Han, K., Li, P. F., Li, Z. F., Hu, W., … Li, Y. Z. (2013). Diversity of epothilone producers among Sorangium strains in producer-positive soil habitats. Microbial Biotechnology, 7, 130-141.
Müller, R. (2009). Biosynthesis and heterologous production of epothilones. Fortschritte Der Chemie Organischer Naturstoffe, 90, 29-53.
Peng, R., Wang, Y. E., Feng, W.-W., Yue, X.-J., Chen, J.-H., Hu, X.-Z., … Li, Y.-Z. (2018). CRISPR/dCas9-mediated transcriptional improvement of the biosynthetic gene cluster for the epothilone production in Myxococcus xanthus. Microbial Cell Factories, 17, 1-12.
Tang, L. (2000). Cloning and heterologous expression of the epothilone gene cluster. Science, 287, 640-642.
Verrills, N. M., Flemming, C. L., Liu, M., Ivery, M. T., Cobon, G. S., Norris, M. D., … Kavallaris, M. (2003). Microtubule alterations and mutations induced by desoxyepothilone B. Chemistry & Biology, 10(7), 597-607.
Yue, X.-J., Cui, X.-W., Zhang, Z., Hu, W.-F., Li, Z.-F., Zhang, Y.-M., & Li, Y.-Z. (2018). Effects of transcriptional mode on promoter substitution and tandem engineering for the production of epothilones in Myxococcus xanthus. Applied Microbiology & Biotechnology, 102, 1-12.
Yue, X.-J., Cui, X.-W., Zhang, Z., Hu, W.-F., Li, Z.-F., Zhang, Y.-M., & Li, Y.-Z. (2018). Effects of transcriptional mode on promoter substitution and tandem engineering for the production of epothilones in Myxococcus xanthus. Applied Microbiology and Biotechnology, 102, 5599-5610.
Yue, X.-J., Cui, X.-W., Zhang, Z., Peng, R., Zhang, P., Li, Z.-F., & Li, Y.-Z. (2017). A bacterial negative transcription regulator binding on an inverted repeat in the promoter for epothilone biosynthesis. Microbial Cell Factories, 16, 92.
Zhang, Y.-X., Perry, K., Vinci, V. A., Powell, K., Stemmer, W. P. C., & del Cardayré, S. B. (2002). Genome shuffling leads to rapid phenotypic improvement in bacteria. Nature, 415, 644-646.