Effects of Low-Energy Diet or Exercise on Cardiovascular Function in Working-Age Adults With Type 2 Diabetes: A Prospective, Randomized, Open-Label, Blinded End Point Trial.
Adult
Blood Glucose
/ metabolism
Caloric Restriction
Cardiovascular System
/ physiopathology
Case-Control Studies
Diabetes Mellitus, Type 2
/ complications
Diabetic Angiopathies
/ prevention & control
Diet, Reducing
Exercise
/ physiology
Exercise Test
Exercise Therapy
Female
Heart Failure
/ etiology
Humans
Male
Middle Aged
Single-Blind Method
Ventricular Function, Left
/ physiology
Weight Loss
/ physiology
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
19
01
2020
accepted:
02
03
2020
pubmed:
30
3
2020
medline:
27
2
2021
entrez:
30
3
2020
Statut:
ppublish
Résumé
To confirm the presence of subclinical cardiovascular dysfunction in working-age adults with type 2 diabetes (T2D) and determine whether this is improved by a low-energy meal replacement diet (MRP) or exercise training. This article reports on a prospective, randomized, open-label, blinded end point trial with nested case-control study. Asymptomatic younger adults with T2D were randomized 1:1:1 to a 12-week intervention of Eighty-seven participants with T2D (age 51 ± 7 years, HbA In asymptomatic working-age adults with T2D, exercise training improved diastolic function. Despite beneficial effects of weight loss on glycemic control, concentric LV remodeling, and aortic stiffness, a low-energy MRP did not improve diastolic function.
Identifiants
pubmed: 32220917
pii: dc20-0129
doi: 10.2337/dc20-0129
doi:
Substances chimiques
Blood Glucose
0
Banques de données
ClinicalTrials.gov
['NCT02590822']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1300-1310Subventions
Organisme : Department of Health
ID : ICA-CL-2016-02-017
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/16/47/32190
Pays : United Kingdom
Informations de copyright
© 2020 by the American Diabetes Association.