Post-transplant Lymphoproliferative Disorder in a Patient After Kidney Transplant, 5-Year Follow-up: A Case Report.
Adult
Antibodies, Monoclonal
/ therapeutic use
Antineoplastic Agents
/ therapeutic use
Follow-Up Studies
Humans
Immunosuppression Therapy
/ adverse effects
Immunosuppressive Agents
/ adverse effects
Kidney Transplantation
/ adverse effects
Lymphoma
/ drug therapy
Lymphoproliferative Disorders
/ drug therapy
Journal
Transplantation proceedings
ISSN: 1873-2623
Titre abrégé: Transplant Proc
Pays: United States
ID NLM: 0243532
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
11
01
2020
revised:
17
02
2020
accepted:
22
02
2020
pubmed:
31
3
2020
medline:
29
12
2020
entrez:
31
3
2020
Statut:
ppublish
Résumé
Post-transplant lymphoproliferative disorder (PTLD) is a serious, life-threatening complication in organ transplant patients receiving immunosuppressive therapy. The risk factors include Epstein-Barr virus infection and a cumulative dose of the immunosuppression. We present a 5-year follow-up case of a 28-year-old patient with PTLD in the gastrointestinal tract. In the ninth month after kidney transplant, the patient was hospitalized for pain in the abdomen and diarrhea. Physical examination demonstrated tenderness in the area of the cecum, and colonoscopy revealed ulcerations in the large intestine. Polymorphic lymphoma (PTLD) was found in the collected samples. The patient received monotherapy treatment with anti-CD20 antibodies, resulting in complete remission of disease, confirmed by computed tomography scan and colonoscopy. PTLD may have a different clinical course and should be considered in the differential diagnosis of patients after organ transplant.
Identifiants
pubmed: 32222386
pii: S0041-1345(19)31800-7
doi: 10.1016/j.transproceed.2020.02.083
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antineoplastic Agents
0
Immunosuppressive Agents
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2517-2519Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.