Exercise, redox system and neurodegenerative diseases.

Alzheimer Disease / metabolism Animals Antioxidants / metabolism Brain / metabolism Brain Injuries, Traumatic / metabolism Brain-Derived Neurotrophic Factor / metabolism Exercise / physiology Homeostasis Humans Hypoxia / metabolism Hypoxia-Ischemia, Brain Ischemia / metabolism Neurodegenerative Diseases / metabolism Neuroprotection / physiology Oxidation-Reduction Parkinson Disease / metabolism Reactive Oxygen Species / metabolism Stroke / metabolism
Alzheimer diseases Brain function Exercise Ischemia reperfusion Neuroprotection Parkinson's disease Redox homeostasis

Journal

Biochimica et biophysica acta. Molecular basis of disease
ISSN: 1879-260X
Titre abrégé: Biochim Biophys Acta Mol Basis Dis
Pays: Netherlands
ID NLM: 101731730

Informations de publication

Date de publication:
01 10 2020
Historique:
received: 25 09 2019
revised: 20 03 2020
accepted: 22 03 2020
pubmed: 31 3 2020
medline: 15 12 2020
entrez: 31 3 2020
Statut: ppublish

Résumé

Regular exercise induces a wide range of redox system-associated molecular adaptive responses to the nervous system. The intermittent induction of reactive oxygen species (ROS) during acute exercise sessions and the related upregulation of antioxidant/repair and housekeeping systems are associated with improved physiological function. Exercise-induced proliferation and differentiation of neuronal stem cells are ROS dependent processes. The increased production of brain derived neurotrophic factor (BDNF) and the regulation by regular exercise are dependent upon redox sensitive pathways. ROS are causative and associative factors of neurodegenerative diseases and regular exercise provides significant neuroprotective effects against Alzheimer's disease, Parkinson's disease, and hypoxia/reperfusion related disorders. Regular exercise regulates redox homeostasis in the brain with complex multi-level molecular pathways.

Identifiants

DOI: 10.1016/j.bbadis.2020.165778 PMID: 32222542
pubmed: 32222542
pii: S0925-4439(20)30123-X
doi: 10.1016/j.bbadis.2020.165778
pii:
doi:

Substances chimiques

Antioxidants 0
Brain-Derived Neurotrophic Factor 0
Reactive Oxygen Species 0
BDNF protein, human 7171WSG8A2

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

165778

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest Authors state no conflict of interest.

Auteurs

Helong Quan (H)

Exercise and Metabolism Research Center, Zhejiang Normal University, Jinhua City, Zhejiang, China.

Erika Koltai (E)

Research Institute of Sport Science, University of Physical Education, Budapest, Hungary.

Katsuhiko Suzuki (K)

Faculty of Sport Sciences, Waseda University, Saitama 359-1192, Japan.

Aderbal S Aguiar (AS)

Research Group on Biology of Exercise, Department of Health Sciences, Federal University of Santa Catarina, Santa Catarina, Brazil.

Ricardo Pinho (R)

Laboratory of Exercise Biochemistry in Health, Graduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.

Istvan Boldogh (I)

Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.

Istvan Berkes (I)

Research Institute of Sport Science, University of Physical Education, Budapest, Hungary.

Zsolt Radak (Z)

Research Institute of Sport Science, University of Physical Education, Budapest, Hungary; Faculty of Sport Sciences, Waseda University, Saitama 359-1192, Japan. Electronic address: radak.zsolt@tf.hu.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Exercise, redox system and neurodegenerative diseases.
questionsmedicales.fr › Eucaryotes › Animaux › Exercise, redox system and neurodegenerative diseases.
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Exercise, redox system and neurodegenerative diseases.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Exercise, redox system and neurodegenerative diseases.
questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Traumatismes cranioencéphaliques › Lésions encéphaliques › Lésions traumatiques de l'encéphale › Exercise, redox system and neurodegenerative diseases.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Facteur neurotrophique dérivé du cerveau › Exercise, redox system and neurodegenerative diseases.
questionsmedicales.fr › Activités humaines › Exercice physique › Exercise, redox system and neurodegenerative diseases.
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Exercise, redox system and neurodegenerative diseases.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Exercise, redox system and neurodegenerative diseases.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Exercise, redox system and neurodegenerative diseases.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Hypoxie cérébrale › Hypoxie-ischémie du cerveau › Exercise, redox system and neurodegenerative diseases.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Ischémie › Exercise, redox system and neurodegenerative diseases.
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Exercise, redox system and neurodegenerative diseases.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neuroprotection › Exercise, redox system and neurodegenerative diseases.
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Exercise, redox system and neurodegenerative diseases.
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Exercise, redox system and neurodegenerative diseases.
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Exercise, redox system and neurodegenerative diseases.
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Exercise, redox system and neurodegenerative diseases.