Monoaminergic balances predict non-depression-like phenotype in Learned Helplessness Paradigm.

Animals Dopamine Helplessness, Learned Hydroxyindoleacetic Acid Norepinephrine Phenotype Rats Serotonin
depression dopamine learned helplessness noradrenaline serotonin stress resilience

Journal

Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074

Informations de publication

Date de publication:
01 08 2020
Historique:
received: 22 12 2019
revised: 18 03 2020
accepted: 19 03 2020
pubmed: 31 3 2020
medline: 15 5 2021
entrez: 31 3 2020
Statut: ppublish

Résumé

Monoamine neuronal system abnormality is hypothesized to be the neurochemical pathology in depression, as it is supported by the efficacy of conventional antidepressants. The learned helplessness paradigm generates depression-like (LH) and non-depression-like (non-LH) behavioral models. Examination of the neurochemical states accompanying such distinct behavioral phenotypes can facilitate investigations of the mechanisms underlying resilience and the search for new strategies for depression prevention and therapy. Here, we measured the levels of monoamines, including noradrenaline (NA), serotonin (5-HT), and dopamine (DA), and their metabolites in the medial prefrontal cortex (mPFC), orbitofrontal cortex (OFC), hippocampus, nucleus accumbens (NAc), amygdala, and striatum in LH, non-LH, and non-manipulated (naïve) rats. Compared with LH rats, non-LH rats showed lower 3-methoxy-4-hydroxyphenylglycol (MHPG) levels and NA turnovers in the amygdala and higher 5-HT levels in the NAc. Compared with naïve rats, non-LH rats showed increased DA and homovanillic acid (HVA) levels in the amygdala and increased 5-hydroxyindoleacetic acid (5-HIAA) levels in the hippocampus and NAc, whereas LH rats exhibited increased HVA levels and DA turnovers in the hippocampus, decreased 5-HIAA levels in the mPFC, increased DA turnovers in the OFC, and decreased DA turnovers in the amygdala. Comparison between LH and non-LH suggest that suppressed amygdaloid NA activity and elevated 5-HT activity in the NAc are related to stress resilience. Changes that occurred in LH or non-LH rats when compared with those in naïve rats suggest that suppressed DA activity in the hippocampus and OFC; elevated DA activity in the amygdala; and facilitated 5-HT activity in the hippocampus, mPFC, and NAc are phenomena related to the expression of a non-depression-like phenotype.

Identifiants

DOI: 10.1016/j.neuroscience.2020.03.033 PMID: 32222554
pubmed: 32222554
pii: S0306-4522(20)30192-5
doi: 10.1016/j.neuroscience.2020.03.033
pii:
doi:

Substances chimiques

Serotonin 333DO1RDJY
Hydroxyindoleacetic Acid 54-16-0
Dopamine VTD58H1Z2X
Norepinephrine X4W3ENH1CV

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

290-298

Informations de copyright

Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.

Auteurs

Katsumasa Muneoka (K)

Department of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Japan; Department of Biochemistry, Showa University School of Medicine, Tokyo, Japan.

Yasunori Oda (Y)

Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan.

Masaaki Iwata (M)

Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Yonago, Japan.

Masaomi Iyo (M)

Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan.

Kenji Hashimoto (K)

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

Yukihiko Shirayama (Y)

Department of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Japan; Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan. Electronic address: shirayama@rapid.ocn.ne.jp.

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