Severe worsening of adult-onset Alexander disease after minor head trauma: Report of two patients and review of the literature.
Alexander disease
Leukoencephalopathies
Nervous system trauma
Journal
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
ISSN: 1532-2653
Titre abrégé: J Clin Neurosci
Pays: Scotland
ID NLM: 9433352
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
10
01
2020
accepted:
20
03
2020
pubmed:
1
4
2020
medline:
30
9
2020
entrez:
1
4
2020
Statut:
ppublish
Résumé
Alexander disease (ALXDRD) is a rare astrocytic leukodystrophy caused by GFAP mutations. The adult-onset (AO) variant is usually characterized by gradual onset of spastic ataxia and bulbar symptoms with slowly progressive course. We report two AO-ALXDRD cases with rapid worsening after minor head trauma. In one of them, the only post-traumatic neuroimaging change was revealed by diffusion tensor imaging study. Our observations support the link between head trauma and ALXDRD progression, and suggest that this progression may be ascribed to microstructural changes. Clinicians should inform ALXDRD patients to minimize the risk of head trauma.
Identifiants
pubmed: 32223977
pii: S0967-5868(20)30092-8
doi: 10.1016/j.jocn.2020.03.033
pii:
doi:
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
221-223Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.