DNA Strand Break Properties of Protoporphyrin IX by X-Ray Irradiation against Melanoma.
DNA double-strand break
X-ray
melanoma
photodynamic therapy
protoporphyrin IX
radiodynamic therapy
radiotherapy
reactive oxygen species (ROS)
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Mar 2020
26 Mar 2020
Historique:
received:
29
02
2020
revised:
20
03
2020
accepted:
24
03
2020
entrez:
1
4
2020
pubmed:
1
4
2020
medline:
17
12
2020
Statut:
epublish
Résumé
Recent reports have suggested that 5-aminolevulinic acid (5-ALA), which is a precursor to protoporphyrin IX (PpIX), leads to selective accumulation of PpIX in tumor cells and acts as a radiation sensitizer in vitro and in vivo in mouse models of melanoma, glioma, and colon cancer. In this study, we investigated the effect of PpIX under X-ray irradiation through ROS generation and DNA damage. ROS generation by the interaction between PpIX and X-ray was evaluated by two kinds of probes, 3'-(p-aminophenyl) fluorescein (APF) for hydroxyl radical (•OH) detection and dihydroethidium (DHE) for superoxide (O
Identifiants
pubmed: 32225109
pii: ijms21072302
doi: 10.3390/ijms21072302
pmc: PMC7177738
pii:
doi:
Substances chimiques
Protoporphyrins
0
Radiation-Sensitizing Agents
0
Reactive Oxygen Species
0
Aminolevulinic Acid
88755TAZ87
protoporphyrin IX
C2K325S808
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 18H02705
Organisme : Japan Society for the Promotion of Science
ID : 19K22609
Organisme : Canon Foundation
ID : K16-0073
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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