Current Developments in the Immunology of Psoriasis.
Biologics
Cytokines
Lymphocytes
Psoriasis
Regulatory B cells
Journal
The Yale journal of biology and medicine
ISSN: 1551-4056
Titre abrégé: Yale J Biol Med
Pays: United States
ID NLM: 0417414
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
entrez:
1
4
2020
pubmed:
1
4
2020
medline:
24
4
2021
Statut:
epublish
Résumé
Psoriasis is a frequent inflammatory skin disease. Fundamental research on the pathogenesis of psoriasis has substantially increased our understanding of skin immunology, which has helped to introduce innovative and highly effective therapies. Psoriasis is a largely T lymphocyte-mediated disease in which activation of innate immune cells and pathogenic T cells result in skin inflammation and hyperproliferation of keratinocytes. B cells have thus far largely been neglected regarding their role for the pathogenesis of psoriasis. However, recent data shed light on their role in inflammatory skin diseases. Interestingly, interleukin (IL)-10-producing regulatory B cells have been assumed to ameliorate psoriasis. In this review, we will discuss the development of disease, pathogenicity, and current developments in therapeutic options. We describe different roles of T cells, B cells, and cytokines for the immunopathology and disease course of psoriasis.
Substances chimiques
Biological Products
0
Immunosuppressive Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
97-110Informations de copyright
Copyright ©2020, Yale Journal of Biology and Medicine.
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