Laser-structured spike surface shows great bone integrative properties despite infection in vivo.
Animals
Anti-Bacterial Agents
/ pharmacology
Bacterial Adhesion
/ drug effects
Biofilms
/ drug effects
Implants, Experimental
/ microbiology
Lasers
Male
Prosthesis-Related Infections
/ drug therapy
Rats
Rats, Inbred Lew
Staphylococcal Infections
/ drug therapy
Staphylococcus aureus
/ physiology
Uracil
/ analogs & derivatives
Biofilm
Confocal laser scanning microscopy
Femtosecond laser ablation
Staphylococcus aureus
Structured implant surface
Journal
Materials science & engineering. C, Materials for biological applications
ISSN: 1873-0191
Titre abrégé: Mater Sci Eng C Mater Biol Appl
Pays: Netherlands
ID NLM: 101484109
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
23
05
2019
revised:
25
11
2019
accepted:
18
12
2019
entrez:
2
4
2020
pubmed:
2
4
2020
medline:
29
12
2020
Statut:
ppublish
Résumé
Implant associated infections can result in devastating consequences for patients. One major cause is the formation of bacterial biofilms, which result in increased resistance against antimicrobial therapeutics. A reduction of implant associated infections can be achieved by functionalization of implant surfaces. The generation of three dimensional surface structures by femtosecond laser ablation is one method to fabricate bacterial repellent large scaled surfaces without altering the material chemical composition. The challenge is to reduce bacterial growth while improving cellular ongrowth. For this purpose, spike structures were created as small as possible by used fabrication method on cubic Ti90/Al6/V4-rods and their effectiveness against bacterial colonization was compared to unstructured Ti90/Al6/V4-rods. Rods were implanted in the rat tibia and infected intraoperatively with 10
Identifiants
pubmed: 32228937
pii: S0928-4931(19)31890-9
doi: 10.1016/j.msec.2019.110573
pii:
doi:
Substances chimiques
6-chloro-5-(2-propenyl)-uracil
0
Anti-Bacterial Agents
0
Uracil
56HH86ZVCT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110573Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Disclosures The authors declare that they have no competing interests. Declaration of competing interest The authors declare that they have no competing interests.