Novel PMMA bone cement nanocomposites containing magnesium phosphate nanosheets and hydroxyapatite nanofibers.

Bone Cements / chemistry Compressive Strength Durapatite / chemistry Escherichia coli / drug effects Magnesium Compounds / chemistry Nanocomposites / chemistry Nanofibers / chemistry Phosphates / chemistry Polymethyl Methacrylate / chemistry
Antibacterial property Bioactivity Compressive strength Cytotoxicity HA nanofibers PMMA nanocomposite Two-dimensional magnesium phosphate nanosheets

Journal

Materials science & engineering. C, Materials for biological applications
ISSN: 1873-0191
Titre abrégé: Mater Sci Eng C Mater Biol Appl
Pays: Netherlands
ID NLM: 101484109

Informations de publication

Date de publication:
Apr 2020
Historique:
received: 12 05 2018
revised: 05 11 2019
accepted: 26 11 2019
entrez: 2 4 2020
pubmed: 2 4 2020
medline: 22 12 2020
Statut: ppublish

Résumé

Lack of bioactivity and monomer toxicity are limiting factors of polymethyl methacrylate (PMMA) bone cement in orthopedic applications. Herein, we address these shortcomings by proposing two-dimensional magnesium phosphate (MgP) nanosheets and hydroxyapatite (HA) nanofibers as novel fillers in PMMA bone cement nanocomposites. Two-dimensional MgP nanosheets and one-dimensional HA nanofibers were synthesized by tuning the crystallization of the sodium-magnesium-phosphate ternary system and hydrothermal homogeneous precipitation, respectively. We show that MgP nanosheets exhibit antibacterial properties against Escherichia coli (E. coli). In addition, HA nanofibers with high level of bioactivity are the proper choice to induce cell viability in the nanocomposite. Results indicate that the combination of both fillers can act as deformation locks enhancing the compressive strength of the nanocomposites. The synthesized nanocomposite possesses excellent bioactivity, mechanical properties, and cytocompatibility potentially opening new paradigm in the design of next generation bone cement composites.

Identifiants

DOI: 10.1016/j.msec.2019.110497 PMID: 32228962
pubmed: 32228962
pii: S0928-4931(18)31345-6
doi: 10.1016/j.msec.2019.110497
pii:
doi:

Substances chimiques

Bone Cements 0
Magnesium Compounds 0
Phosphates 0
magnesium phosphate 453COF7817
Polymethyl Methacrylate 9011-14-7
Durapatite 91D9GV0Z28

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

110497

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no conflict of interests.

Auteurs

Abhijit H Phakatkar (AH)

Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA.

Mostafa Rezazadeh Shirdar (MR)

Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA.

Mei-Li Qi (ML)

School of Jiaotong and Civil Engineering, Shandong Jiaotong University, Ji'nan 250357, China; School of Materials Science and Engineering, Shandong University, Ji'nan, 250061, China.

Mohammad Mahdi Taheri (MM)

Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA.

Surya Narayanan (S)

Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA.

Tara Foroozan (T)

Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA.

Soroosh Sharifi-Asl (S)

Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA.

Zhennan Huang (Z)

Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA.

Megha Agrawal (M)

Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA.

Yu-Peng Lu (YP)

School of Jiaotong and Civil Engineering, Shandong Jiaotong University, Ji'nan 250357, China.

Reza Shahbazian-Yassar (R)

Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA. Electronic address: rsyassar@uic.edu.

Tolou Shokuhfar (T)

Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA. Electronic address: tolou@uic.edu.

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Classifications MeSH

questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Matières plastiques › Résines synthétiques › Ciments osseux › Novel PMMA bone cement nanocomposites...
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Résistance à la compression › Novel PMMA bone cement nanocomposites...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du phosphore › Acides du phosphore › Acides phosphoriques › Phosphates › Phosphates de calcium › Apatites › Hydroxyapatites › Durapatite › Novel PMMA bone cement nanocomposites...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Novel PMMA bone cement nanocomposites...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du magnésium › Novel PMMA bone cement nanocomposites...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanocomposites › Novel PMMA bone cement nanocomposites...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanofibres › Novel PMMA bone cement nanocomposites...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du phosphore › Acides du phosphore › Acides phosphoriques › Phosphates › Novel PMMA bone cement nanocomposites...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Matières plastiques › Résines synthétiques › Résines acryliques › Poly(acides méthacryliques) › Méthacrylates de méthyle › Poly(méthacrylate de méthyle) › Novel PMMA bone cement nanocomposites...