Excretion of the Polymyxin Derivative NAB739 in Murine Urine.
NAB739
extremely multiresistant strains of Enterobacteriaceae
mouse pyelonephritis
polymyxin B
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
27 Mar 2020
27 Mar 2020
Historique:
received:
27
02
2020
revised:
19
03
2020
accepted:
25
03
2020
entrez:
2
4
2020
pubmed:
2
4
2020
medline:
2
4
2020
Statut:
epublish
Résumé
Extremely multiresistant strains of Enterobacteriaceae are emerging and spreading at a worrisome pace. Polymyxins are used as the last-resort therapy against such strains, in spite of their nephrotoxicity. We have previously shown that novel polymyxin derivatives NAB739 and NAB815 are less nephrotoxic in cynomolgus monkeys than polymyxin B and are therapeutic in murine
Identifiants
pubmed: 32230751
pii: antibiotics9040143
doi: 10.3390/antibiotics9040143
pmc: PMC7235871
pii:
doi:
Types de publication
Journal Article
Langues
eng
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