A new algorithm to convert a normal antibody into the corresponding catalytic antibody.
Algorithms
Amino Acid Sequence
Amino Acid Substitution
Amyloid beta-Peptides
/ chemistry
Antibodies, Catalytic
/ chemistry
Antibodies, Monoclonal
/ chemistry
Catalysis
Chromatography, High Pressure Liquid
Hydrolysis
Immunoglobulin Light Chains
/ chemistry
Models, Molecular
Mutation
Peptide Fragments
/ chemistry
Protein Conformation
Protein Multimerization
Proteolysis
Recombinant Proteins
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
05
07
2019
accepted:
31
12
2019
entrez:
2
4
2020
pubmed:
2
4
2020
medline:
25
11
2020
Statut:
epublish
Résumé
Over thousands of monoclonal antibodies (mAbs) have been produced so far, and it would be valuable if these mAbs could be directly converted into catalytic antibodies. We have designed a system to realize the above concept by deleting Pro
Identifiants
pubmed: 32232151
doi: 10.1126/sciadv.aay6441
pii: aay6441
pmc: PMC7096177
doi:
Substances chimiques
Amyloid beta-Peptides
0
Antibodies, Catalytic
0
Antibodies, Monoclonal
0
Immunoglobulin Light Chains
0
Peptide Fragments
0
Recombinant Proteins
0
amyloid beta-protein (1-40)
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eaay6441Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
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