Red-Emitting Dibenzodiazepinone Derivatives as Fluorescent Dualsteric Probes for the Muscarinic Acetylcholine M

Animals CHO Cells Cholinergic Agents / chemistry Cricetulus Fluorescent Dyes / chemistry Muscarinic Antagonists / chemistry Phthalimides / chemistry Protein Structure, Secondary Quaternary Ammonium Compounds / chemistry Receptor, Muscarinic M2 / antagonists & inhibitors

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
23 04 2020
Historique:
pubmed: 3 4 2020
medline: 25 9 2020
entrez: 3 4 2020
Statut: ppublish

Résumé

Fluorescently labeled dibenzodiazepinone-type muscarinic acetylcholine receptor (MR) antagonists, including dimeric ligands, were prepared using red-emitting cyanine dyes. Probes containing a fluorophore with negative charge showed high M

Identifiants

DOI: 10.1021/acs.jmedchem.9b02172 PMID: 32233403
pubmed: 32233403
doi: 10.1021/acs.jmedchem.9b02172
doi:

Substances chimiques

Cholinergic Agents 0
Fluorescent Dyes 0
Muscarinic Antagonists 0
Phthalimides 0
Quaternary Ammonium Compounds 0
Receptor, Muscarinic M2 0
W84 compound 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4133-4154

Auteurs

Xueke She (X)

Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstr. 31, D-93053 Regensburg, Germany.

Andrea Pegoli (A)

Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstr. 31, D-93053 Regensburg, Germany.

Corinna G Gruber (CG)

Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstr. 31, D-93053 Regensburg, Germany.

David Wifling (D)

Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstr. 31, D-93053 Regensburg, Germany.

Jessica Carpenter (J)

School of Life Sciences, University of Nottingham, Queen's Medical Centre, Derby Road, Nottingham NG7 2UH, U.K.

Harald Hübner (H)

Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich Alexander University, Nikolaus-Fiebiger-Straße 10, D-91058 Erlangen, Germany.

Mengya Chen (M)

Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstr. 31, D-93053 Regensburg, Germany.

Jianfei Wan (J)

Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstr. 31, D-93053 Regensburg, Germany.

Günther Bernhardt (G)

Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstr. 31, D-93053 Regensburg, Germany.
ORCID: 0000-0001-6491-9874

Peter Gmeiner (P)

Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich Alexander University, Nikolaus-Fiebiger-Straße 10, D-91058 Erlangen, Germany.
ORCID: 0000-0002-4127-197X

Nicholas D Holliday (ND)

School of Life Sciences, University of Nottingham, Queen's Medical Centre, Derby Road, Nottingham NG7 2UH, U.K.
ORCID: 0000-0002-2900-828X

Max Keller (M)

Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstr. 31, D-93053 Regensburg, Germany.
ORCID: 0000-0002-8095-8627

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Red-Emitting Dibenzodiazepinone Derivatives as...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules CHO › Red-Emitting Dibenzodiazepinone Derivatives as...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Red-Emitting Dibenzodiazepinone Derivatives as...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Cricetulus › Red-Emitting Dibenzodiazepinone Derivatives as...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Luminescents › Colorants fluorescents › Red-Emitting Dibenzodiazepinone Derivatives as...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Antagonistes cholinergiques › Antagonistes muscariniques › Red-Emitting Dibenzodiazepinone Derivatives as...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoindoles › Phtalimides › Red-Emitting Dibenzodiazepinone Derivatives as...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Red-Emitting Dibenzodiazepinone Derivatives as...
questionsmedicales.fr › Composés chimiques organiques › Composés onium › Composés d'ammonium quaternaire › Red-Emitting Dibenzodiazepinone Derivatives as...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteur muscarinique › Récepteur muscarinique de type M2 › Red-Emitting Dibenzodiazepinone Derivatives as...