Controversies around the function of LARP1.
Animals
Autoantigens
/ chemistry
Binding Sites
Carrier Proteins
Gene Expression Regulation
Humans
Multigene Family
Protein Binding
Protein Interaction Domains and Motifs
RNA
/ chemistry
RNA Cleavage
RNA-Binding Proteins
/ chemistry
Ribonucleoproteins
/ chemistry
Signal Transduction
Substrate Specificity
SS-B Antigen
LARP
LARP1
La-related protein 1
PABP
cancer
mRNA
mTOR
mTORC1
poly A binding protein
translation
Journal
RNA biology
ISSN: 1555-8584
Titre abrégé: RNA Biol
Pays: United States
ID NLM: 101235328
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
pubmed:
3
4
2020
medline:
1
12
2021
entrez:
3
4
2020
Statut:
ppublish
Résumé
The RNA-binding protein LARP1 has generated interest in recent years for its role in the mTOR signalling cascade and its regulation of terminal oligopyrimidine (TOP) mRNA translation. Paradoxically, some scientists have shown that LARP1 represses TOP translation while others that LARP1 activates it. Here, we present opinions from four leading scientists in the field to discuss these and other contradictory findings.
Identifiants
pubmed: 32233986
doi: 10.1080/15476286.2020.1733787
pmc: PMC7928164
doi:
Substances chimiques
Autoantigens
0
Carrier Proteins
0
RNA-Binding Proteins
0
Ribonucleoproteins
0
RNA
63231-63-0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
207-217Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM116889
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM125955
Pays : United States
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