Effect of Muscle Mass Loss After Esophagectomy on Prognosis of Oesophageal Cancer.
Aged
Disease-Free Survival
Esophageal Neoplasms
/ pathology
Esophagectomy
/ adverse effects
Esophagogastric Junction
/ pathology
Female
Follow-Up Studies
Humans
Male
Middle Aged
Multivariate Analysis
Muscular Disorders, Atrophic
/ etiology
Prognosis
Retrospective Studies
Stomach Neoplasms
/ pathology
Muscle mass loss
esophagectomy
oesophageal cancer
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
22
02
2020
revised:
02
03
2020
accepted:
04
03
2020
entrez:
3
4
2020
pubmed:
3
4
2020
medline:
21
4
2020
Statut:
ppublish
Résumé
To assess the prognostic effect of muscle loss after esophagectomy and before discharge. This study retrospectively analysed 159 consecutive patients with oesophageal and gastroesophageal junction cancer who underwent esophagectomy between August 2011 and October 2015. Body composition was evaluated one week before surgery and at discharge using a bioelectrical impedance analyser. The median rate of muscle mass loss (RMML) was 4.38% (range=-3.3 to +18.8). Patients with increased RMML had significantly poorer outcomes of overall survival than those with decreased RMML (p=0.015). On multivariate analysis, RMML [≥4.38, hazard ratio (HR)=2.033, 95% confidence interval (CI)=1.018-5.924, p=0.044) and pathological tumour depth (≥2, HR=3.099, 95%CI=1.339-7.172, p=0.008) were selected as independent prognostic factors. RMML after esophagectomy is indicative of poor prognosis in patients with esophageal cancer.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
To assess the prognostic effect of muscle loss after esophagectomy and before discharge.
PATIENTS AND METHODS
METHODS
This study retrospectively analysed 159 consecutive patients with oesophageal and gastroesophageal junction cancer who underwent esophagectomy between August 2011 and October 2015. Body composition was evaluated one week before surgery and at discharge using a bioelectrical impedance analyser.
RESULTS
RESULTS
The median rate of muscle mass loss (RMML) was 4.38% (range=-3.3 to +18.8). Patients with increased RMML had significantly poorer outcomes of overall survival than those with decreased RMML (p=0.015). On multivariate analysis, RMML [≥4.38, hazard ratio (HR)=2.033, 95% confidence interval (CI)=1.018-5.924, p=0.044) and pathological tumour depth (≥2, HR=3.099, 95%CI=1.339-7.172, p=0.008) were selected as independent prognostic factors.
CONCLUSION
CONCLUSIONS
RMML after esophagectomy is indicative of poor prognosis in patients with esophageal cancer.
Identifiants
pubmed: 32234926
pii: 40/4/2275
doi: 10.21873/anticanres.14192
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2275-2281Informations de copyright
Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.