Association of Triiodothyronine Levels With Prostate Cancer Histopathological Differentiation and Tumor Stage.

Aged Humans Male Middle Aged Neoplasm Grading Neoplasm Staging Preoperative Period Prospective Studies Prostate-Specific Antigen / blood Prostatectomy / methods Prostatic Neoplasms / blood Thyrotropin / blood Thyroxine / blood Triiodothyronine / blood
Grade Groups Prostate cancer pathological T stage prostatectomy thyroid hormones triiodothyronine tumor percentage involvement

Journal

Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988

Informations de publication

Date de publication:
Apr 2020
Historique:
received: 12 02 2020
revised: 02 03 2020
accepted: 13 03 2020
entrez: 3 4 2020
pubmed: 3 4 2020
medline: 21 4 2020
Statut: ppublish

Résumé

The aim of this study was to determine the association between total triiodothyronine (T3), free fraction of thyroxin (FT4), and thyrotropin (TSH) levels with prostate cancer histopathological features. Blood samples from 140 patients with prostate cancer were analyzed preoperatively and stratified according to postoperative histopathological differentiation. The first group (N=62) included patients with prostate cancer Grade Groups (GG) 1-2, while the second group (N=63) included patients with prostate cancer GG 3-5. T3 levels were significantly higher in patients with prostate cancer GG 3-5 (p=0.047). There was no significant difference in the FT4 and TSH levels between the two groups (p=0.680 and 0.801, respectively). T3 levels were positively correlated with tumor percentage involvement (TPI) (p=0.002), and pT stage (p=0.047) on definitive pathology. Higher T3 levels are associated with several indicators of prostate cancer histopathological aggressiveness.

Sections du résumé

BACKGROUND/AIM OBJECTIVE
The aim of this study was to determine the association between total triiodothyronine (T3), free fraction of thyroxin (FT4), and thyrotropin (TSH) levels with prostate cancer histopathological features.
PATIENTS AND METHODS METHODS
Blood samples from 140 patients with prostate cancer were analyzed preoperatively and stratified according to postoperative histopathological differentiation. The first group (N=62) included patients with prostate cancer Grade Groups (GG) 1-2, while the second group (N=63) included patients with prostate cancer GG 3-5.
RESULTS RESULTS
T3 levels were significantly higher in patients with prostate cancer GG 3-5 (p=0.047). There was no significant difference in the FT4 and TSH levels between the two groups (p=0.680 and 0.801, respectively). T3 levels were positively correlated with tumor percentage involvement (TPI) (p=0.002), and pT stage (p=0.047) on definitive pathology.
CONCLUSION CONCLUSIONS
Higher T3 levels are associated with several indicators of prostate cancer histopathological aggressiveness.

Identifiants

DOI: 10.21873/anticanres.14199 PMID: 32234933
pubmed: 32234933
pii: 40/4/2323
doi: 10.21873/anticanres.14199
doi:

Substances chimiques

Triiodothyronine 06LU7C9H1V
Thyrotropin 9002-71-5
Prostate-Specific Antigen EC 3.4.21.77
Thyroxine Q51BO43MG4

Types de publication

Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

2323-2329

Informations de copyright

Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Auteurs

Petra Petranović Ovčariček (PP)

Department of Oncology and Nuclear Medicine, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia p.petranovic@gmail.com.

Ana Fröbe (A)

Department of Oncology and Nuclear Medicine, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia.
School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

Frederik Anton Verburg (FA)

Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany.

Jure Murgić (J)

Department of Oncology and Nuclear Medicine, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia.

Marija Bosak Butković (MB)

Department of Oncology and Nuclear Medicine, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia.

Slaven Ovčariček (S)

Department of Urology, Clinical Hospital Sveti Duh, Zagreb, Croatia.

Berislav Mažuran (B)

Department of Urology, Clinical Hospital Sveti Duh, Zagreb, Croatia.
Catholic University of Croatia, Zagreb, Croatia.

Božo Krušlin (B)

Department of Pathology and Cytology Ljudevit Jurak, University Hospital Center Sestre milosrdnice, Zagreb, Croatia.
School of Medicine, University of Zagreb, Zagreb, Croatia.

Danica Jakovčević (D)

Department of Pathology, Clinical Hospital Sveti Duh, Zagreb, Croatia.

Šoip Šoipi (Š)

Department of Urology, University Hospital Center Sestre milosrdnice, Zagreb, Croatia.

Boris Ružić (B)

School of Medicine, University of Zagreb, Zagreb, Croatia.
Department of Urology, University Hospital Center Sestre milosrdnice, Zagreb, Croatia.

Milan Milošević (M)

School of Medicine, University of Zagreb, Zagreb, Croatia.
Department for Environmental Health, Occupational and Sports Medicine, Andrija Štampar School of Public Health, Zagreb, Croatia.

Dražena Krilić (D)

Department of Oncology and Nuclear Medicine, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia.

Maja Franceschi (M)

Department of Oncology and Nuclear Medicine, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia.
Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.

Tomislav Jukić (T)

Department of Oncology and Nuclear Medicine, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia.
School of Medicine, University of Zagreb, Zagreb, Croatia.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Association of Triiodothyronine Levels With...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association of Triiodothyronine Levels With...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Association of Triiodothyronine Levels With...
questionsmedicales.fr › Diagnostic › Pronostic › Grading des tumeurs › Association of Triiodothyronine Levels With...
questionsmedicales.fr › Diagnostic › Pronostic › Stadification tumorale › Association of Triiodothyronine Levels With...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Soins aux patients › Période périopératoire › Période préopératoire › Association of Triiodothyronine Levels With...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Association of Triiodothyronine Levels With...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Antigène spécifique de la prostate › Association of Triiodothyronine Levels With...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie urogénitale › Procédures de chirurgie urologique › Procédures de chirurgie urologique masculine › Prostatectomie › Association of Triiodothyronine Levels With...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital mâle › Tumeurs de la prostate › Association of Triiodothyronine Levels With...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones hypophysaires › Hormones antéhypophysaires › Thyréostimuline › Association of Triiodothyronine Levels With...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés cycliques › Acides aminés aromatiques › Thyroxine › Association of Triiodothyronine Levels With...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés cycliques › Acides aminés aromatiques › Thyroxine › Thyronines › Tri-iodothyronine › Association of Triiodothyronine Levels With...