Statistical and Functional Studies Identify Epistasis of Cardiovascular Risk Genomic Variants From Genome-Wide Association Studies.
Cardiovascular Diseases
/ diagnosis
Case-Control Studies
Cells, Cultured
Data Interpretation, Statistical
Endothelial Cells
/ metabolism
Epistasis, Genetic
Gene Regulatory Networks
Genetic Predisposition to Disease
Genome-Wide Association Study
Heart Disease Risk Factors
Humans
Male
Membrane Proteins
/ genetics
Middle Aged
Models, Statistical
Nerve Tissue Proteins
/ genetics
Phenotype
RNA, Long Noncoding
/ genetics
Risk Assessment
Transcriptome
Genome‐wide Association Studies
TMEM106B
coronary artery disease
gene‐gene interactions
long non‐coding RNA (lncRNA) ANRIL (CDKN2B‐AS1)
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
07 04 2020
07 04 2020
Historique:
entrez:
3
4
2020
pubmed:
3
4
2020
medline:
9
3
2021
Statut:
ppublish
Résumé
Background Epistasis describes how gene-gene interactions affect phenotypes, and could have a profound impact on human diseases such as coronary artery disease (CAD). The goal of this study was to identify gene-gene interactions in CAD using an easily generalizable multi-stage approach. Methods and Results Our forward genetic approach consists of multiple steps that combine statistical and functional approaches, and analyze information from global gene expression profiling, functional interactions, and genetic interactions to robustly identify gene-gene interactions. Global gene expression profiling shows that knockdown of
Identifiants
pubmed: 32237974
doi: 10.1161/JAHA.119.014146
pmc: PMC7428625
doi:
Substances chimiques
ADTRP protein, human
0
CDKN2B antisense RNA, human
0
Membrane Proteins
0
Nerve Tissue Proteins
0
RNA, Long Noncoding
0
TMEM106B protein, human
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e014146Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL121358
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL126729
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL138465
Pays : United States
Organisme : Medical Research Council
ID : MR/P015514/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/D/30002276
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N003179/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R025851/1
Pays : United Kingdom
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