Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine (TETS) in mice.
Animals
Biotransformation
Brain
/ drug effects
Bridged-Ring Compounds
/ pharmacokinetics
Convulsants
/ pharmacokinetics
GABA Antagonists
/ pharmacokinetics
Lethal Dose 50
Male
Mice
Picrotoxin
/ analogs & derivatives
Receptors, GABA-A
/ metabolism
Seizures
/ chemically induced
Sesterterpenes
Tissue Distribution
Toxicokinetics
Convulsant
GABAA receptor
Picrotoxinin
TETS
Threat agent
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
01
11
2019
accepted:
26
03
2020
pubmed:
3
4
2020
medline:
13
7
2021
entrez:
3
4
2020
Statut:
ppublish
Résumé
Acute intoxication with picrotoxin or the rodenticide tetramethylenedisulfotetramine (TETS) can cause seizures that rapidly progress to status epilepticus and death. Both compounds inhibit γ-aminobutyric acid type-A (GABA
Identifiants
pubmed: 32239239
doi: 10.1007/s00204-020-02728-z
pii: 10.1007/s00204-020-02728-z
pmc: PMC7303059
mid: NIHMS1603303
doi:
Substances chimiques
Bridged-Ring Compounds
0
Convulsants
0
GABA Antagonists
0
Gabra2 protein, mouse
0
Gabrb3 protein, mouse
0
Gabrg2 protein, mouse
0
Receptors, GABA-A
0
Sesterterpenes
0
Picrotoxin
124-87-8
picrotoxinin
9K011NUF0R
tetramethylenedisulfotetramine
F6TS3WME05
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1995-2007Subventions
Organisme : NIEHS NIH HHS
ID : R35 ES030443
Pays : United States
Organisme : NINDS NIH HHS
ID : U54 NS079202
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM099608
Pays : United States
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