Two novel pleiotropic loci associated with osteoporosis and abdominal obesity.

Animals Body Mass Index Cohort Studies Female Femur Neck / physiology Genetic Pleiotropy / genetics Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Interferon-gamma / genetics Male Mendelian Randomization Analysis Mice Mice, Knockout Obesity, Abdominal / genetics Osteoporosis / genetics Polymorphism, Single Nucleotide / genetics Promoter Regions, Genetic / genetics Protein Kinase C-theta / genetics Quantitative Trait Loci / genetics

Journal

Human genetics
ISSN: 1432-1203
Titre abrégé: Hum Genet
Pays: Germany
ID NLM: 7613873

Informations de publication

Date de publication:
Aug 2020
Historique:
received: 25 12 2019
accepted: 24 03 2020
pubmed: 3 4 2020
medline: 18 8 2020
entrez: 3 4 2020
Statut: ppublish

Résumé

Aiming to uncover a shared genetic basis of abdominal obesity and osteoporosis, we performed a bivariate GWAS meta-analysis of femoral neck BMD (FNK-BMD) and trunk fat mass adjusted by trunk lean mass (TFM

Identifiants

DOI: 10.1007/s00439-020-02155-1 PMID: 32239398 PMC: PMC7883472
pubmed: 32239398
doi: 10.1007/s00439-020-02155-1
pii: 10.1007/s00439-020-02155-1
pmc: PMC7883472
mid: NIHMS1667047
doi:

Substances chimiques

IFNG protein, human 0
Interferon-gamma 82115-62-6
PRKCQ protein, human EC 2.7.11.13
Protein Kinase C-theta EC 2.7.11.13

Types de publication

Journal Article Meta-Analysis

Langues

eng

Sous-ensembles de citation

IM

Pagination

1023-1035

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH118695
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR059781
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK115679
Pays : United States
Organisme : Inner Mongolia Autonomous Region medical health science & technology research program
ID : 201702180
Organisme : NIGMS NIH HHS
ID : R01 GM109068
Pays : United States
Organisme : National Natural Science Foundation of China
ID : 31571291
Organisme : NIA NIH HHS
ID : U19 AG055373
Pays : United States
Organisme : National Natural Science Foundation of China
ID : 31501026
Organisme : NHLBI NIH HHS
ID : N01HC25195
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH107354
Pays : United States
Organisme : National Natural Science Foundation of China
ID : 31771417
Organisme : WHI NIH HHS
ID : N01WH22110
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB020407
Pays : United States
Organisme : NIH HHS
ID : R01DK115679
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG061917
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB006841
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR069055
Pays : United States
Organisme : NHLBI NIH HHS
ID : N02HL64278
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR041398
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM109036
Pays : United States
Organisme : NIH HHS
ID : R01GM109068
Pays : United States
Organisme : NIH HHS
ID : R01MH107354
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH104680
Pays : United States

Références

Nature. 2010 Oct 28;467(7319):1061-73
pubmed: 20981092
Fertil Steril. 1993 Apr;59(4):707-25
pubmed: 8458485
Nat Commun. 2018 Jan 15;9(1):224
pubmed: 29335400
Lancet. 2005 Oct 1;366(9492):1197-209
pubmed: 16198769
J Immunol. 2001 Sep 1;167(5):2625-31
pubmed: 11509604
Ann Hum Genet. 2009 Nov;73(Pt 6):601-13
pubmed: 19702646
Am J Clin Nutr. 2006 Jan;83(1):146-54
pubmed: 16400063
Bioinformatics. 2014 Jul 1;30(13):1876-83
pubmed: 24618466
Am J Med. 1997 Oct;103(4):274-80
pubmed: 9382119
PLoS Genet. 2011 Apr;7(4):e1001372
pubmed: 21533022
Nature. 2015 Oct 1;526(7571):112-7
pubmed: 26367794
Bioinformatics. 2016 May 15;32(10):1493-501
pubmed: 26773131
Nat Genet. 2018 Nov;50(11):1593-1599
pubmed: 30349118
J Clin Endocrinol Metab. 2015 Nov;100(11):E1457-66
pubmed: 26312577
J Bone Miner Res. 2018 Jun;33(6):1044-1051
pubmed: 29473973
Nat Genet. 2012 Apr 15;44(5):491-501
pubmed: 22504420
Nat Genet. 2009 Nov;41(11):1199-206
pubmed: 19801982
PLoS One. 2009 Aug 28;4(8):e6827
pubmed: 19714249
Behav Genet. 1997 Jul;27(4):325-51
pubmed: 9519560
Curr Osteoporos Rep. 2013 Mar;11(1):30-5
pubmed: 23288547
Control Clin Trials. 1998 Feb;19(1):61-109
pubmed: 9492970
Hum Mol Genet. 2014 Feb 1;23(3):820-30
pubmed: 24064335
Nucleic Acids Res. 2012 Jan;40(Database issue):D930-4
pubmed: 22064851
J Trace Elem Med Biol. 2012 Jun;26(2-3):149-52
pubmed: 22575536
Gigascience. 2015 Feb 25;4:7
pubmed: 25722852
Horm Mol Biol Clin Investig. 2014 Jan;17(1):13-27
pubmed: 25372727
Bone. 1996 Nov;19(5):421-8
pubmed: 8922639
Clin Cases Miner Bone Metab. 2014 Jan;11(1):9-14
pubmed: 25002873
PLoS One. 2018 Jul 26;13(7):e0200785
pubmed: 30048462
Am J Hum Genet. 2018 Jan 4;102(1):88-102
pubmed: 29304378
Obes Surg. 2008 Sep;18(9):1134-43
pubmed: 18563500
Nat Genet. 2013 Jun;45(6):580-5
pubmed: 23715323
Nature. 2016 Sep 22;537(7621):508-514
pubmed: 27626380
N Engl J Med. 2008 Nov 13;359(20):2105-20
pubmed: 19005195
PLoS One. 2009 Aug 04;4(8):e6502
pubmed: 19652719
JAMA. 1998 Dec 2;280(21):1843-8
pubmed: 9846779
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
J Clin Endocrinol Metab. 2018 Jan 1;103(1):125-138
pubmed: 29145611
Bioinformatics. 2010 Sep 15;26(18):2336-7
pubmed: 20634204
PLoS Biol. 2011 Apr;9(4):e1001046
pubmed: 21526222
Metabolism. 2012 Aug;61(8):1152-61
pubmed: 22386937
Nat Genet. 2017 Oct;49(10):1468-1475
pubmed: 28869591
Hum Mol Genet. 2014 Apr 1;23(7):1923-33
pubmed: 24249740
PLoS One. 2011;6(11):e27312
pubmed: 22125610
J Clin Endocrinol Metab. 2007 May;92(5):1640-6
pubmed: 17299077
PLoS Genet. 2013 May;9(5):e1003520
pubmed: 23737753
Nature. 2015 Feb 12;518(7538):197-206
pubmed: 25673413
PLoS One. 2009 Dec 02;4(12):e8133
pubmed: 19956578
Nat Genet. 2019 Feb;51(2):258-266
pubmed: 30598549
Mol Cell Endocrinol. 2014 Jan 25;382(1):740-757
pubmed: 22963884
Genet Epidemiol. 2000 Sep;19(2):160-77
pubmed: 10962476

Auteurs

Lu Liu (L)

Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College, Soochow University, 199 Ren-ai Rd, Suzhou, 215123, Jiangsu, People's Republic of China.
Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Kunshan Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu, People's Republic of China.

Xiao-Lin Yang (XL)

Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College, Soochow University, 199 Ren-ai Rd, Suzhou, 215123, Jiangsu, People's Republic of China.
Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.

Hong Zhang (H)

Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College, Soochow University, 199 Ren-ai Rd, Suzhou, 215123, Jiangsu, People's Republic of China.
Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.

Zi-Jia Zhang (ZJ)

People's Hospital of Inner Mongolia Autonomous Region, Hohhot, Inner Mongolia Autonomous Region, People's Republic of China.

Xin-Tong Wei (XT)

Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Department of Epidemiology and Health Statistics, School of Public Health, Medical College, Soochow University, 199 Ren-ai Rd., Suzhou, 215123, Jiangsu, People's Republic of China.

Gui-Juan Feng (GJ)

Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Department of Epidemiology and Health Statistics, School of Public Health, Medical College, Soochow University, 199 Ren-ai Rd., Suzhou, 215123, Jiangsu, People's Republic of China.

Ju Liu (J)

Kunshan Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu, People's Republic of China.

Hui-Ping Peng (HP)

Kunshan Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu, People's Republic of China.

Rong Hai (R)

Health Commission of Inner Mongolia Autonomous Region, Hohhot, Inner Mongolia Autonomous Region, People's Republic of China.

Hui Shen (H)

Tulane Center for Genomics and Bioinformatics, Department of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal St., Suite 2001, New Orleans, LA, 70112, USA.

Qing Tian (Q)

Tulane Center for Genomics and Bioinformatics, Department of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal St., Suite 2001, New Orleans, LA, 70112, USA.

Hong-Wen Deng (HW)

Tulane Center for Genomics and Bioinformatics, Department of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal St., Suite 2001, New Orleans, LA, 70112, USA. hdeng2@tulane.edu.

Yu-Fang Pei (YF)

Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China. ypei@suda.edu.cn.
Department of Epidemiology and Health Statistics, School of Public Health, Medical College, Soochow University, 199 Ren-ai Rd., Suzhou, 215123, Jiangsu, People's Republic of China. ypei@suda.edu.cn.

Lei Zhang (L)

Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College, Soochow University, 199 Ren-ai Rd, Suzhou, 215123, Jiangsu, People's Republic of China. lzhang6@suda.edu.cn.
Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China. lzhang6@suda.edu.cn.

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