Understanding oncogenicity of cancer driver genes and mutations in the cancer genomics era.
cancer drivers
cancer genes
multiscale analysis
personalized medicine
variants of unknown significance
Journal
FEBS letters
ISSN: 1873-3468
Titre abrégé: FEBS Lett
Pays: England
ID NLM: 0155157
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
03
11
2019
revised:
23
01
2020
accepted:
09
02
2020
pubmed:
3
4
2020
medline:
4
6
2021
entrez:
3
4
2020
Statut:
ppublish
Résumé
One of the key challenges of cancer biology is to catalogue and understand the somatic genomic alterations leading to cancer. Although alternative definitions and search methods have been developed to identify cancer driver genes and mutations, analyses of thousands of cancer genomes return a remarkably similar catalogue of around 300 genes that are mutated in at least one cancer type. Yet, many features of these genes and their role in cancer remain unclear, first and foremost when a somatic mutation is truly oncogenic. In this review, we first summarize some of the recent efforts in completing the catalogue of cancer driver genes. Then, we give an overview of different aspects that influence the oncogenicity of somatic mutations in the core cancer driver genes, including their interactions with the germline genome, other cancer driver mutations, the immune system, or their potential role in healthy tissues. In the coming years, this research holds promise to illuminate how, when, and why cancer driver genes and mutations are really drivers, and thereby move personalized cancer medicine and targeted therapies forward.
Identifiants
pubmed: 32239503
doi: 10.1002/1873-3468.13781
pmc: PMC7529711
mid: NIHMS1584848
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4233-4246Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM118187
Pays : United States
Informations de copyright
© 2020 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
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