Effects of blood pump orientation on performance: In vitro assessment of universal advanced ventricular assist device.
bench testing
hydrodynamic bearing
mechanical circulatory support
pulsatility
regurgitant flow
Journal
Artificial organs
ISSN: 1525-1594
Titre abrégé: Artif Organs
Pays: United States
ID NLM: 7802778
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
04
11
2019
revised:
25
02
2020
accepted:
25
03
2020
pubmed:
3
4
2020
medline:
12
10
2021
entrez:
3
4
2020
Statut:
ppublish
Résumé
An advanced ventricular assist device (VAD), which is under development in our institution, has specific features that allow changes in the axial rotor position and pump performance by intrapump pressure difference. However, performance could be influenced by the pump orientation because of the effect of gravity on the rotor position. The purpose of this study was to evaluate the effects of pump orientation on the pump performance, including pulse pressure and regurgitant flow through the pump when the pump was stopped. Bench testing of the VAD was performed on a static or pulsatile mock loop with a pneumatic device to simulate the native ventricle. The pump performance, including pressure-flow curve, pulsatility, and regurgitant flow, was evaluated at several angles, ranging from -90° (inlet pointed upward) to +90° (inlet pointed downward) at pump speeds of 2000, 2500, 3000, and 3500 rpm. The pump performance was slightly lower at +90° at all rotational speeds, compared with -90°. The pulse pressure on the pulsatile mock loop (80 bpm) was 50 mm Hg without pump support, remained at 50 mm Hg during pump support, and was not changed by orientation (-90°, 0°, and +90°). When the pump was stopped, the regurgitant flow was near 0 L/min at all angles. Pump orientation had a minor effect on pump performance, with no effect on pulse pressure or regurgitant flow when the pump was stopped. This indicates that the effect of gravity on the rotor assembly is insignificant.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1055-1060Subventions
Organisme : NHLBI NIH HHS
ID : R21 HL133871
Pays : United States
Organisme : NHLBI NIH HHS
ID : 5R21HL133871
Pays : United States
Informations de copyright
© 2020 International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC.
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