Meta-analysis of response inhibition in juvenile myoclonic epilepsy.
Executive function
Impulsivity
JME
Psychosocial
Stroop task
Journal
Epilepsy & behavior : E&B
ISSN: 1525-5069
Titre abrégé: Epilepsy Behav
Pays: United States
ID NLM: 100892858
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
12
11
2019
revised:
20
02
2020
accepted:
08
03
2020
pubmed:
3
4
2020
medline:
20
1
2021
entrez:
3
4
2020
Statut:
ppublish
Résumé
Patients with juvenile myoclonic epilepsy (JME) show evidence of cognitive impulsivity that may be linked to later adverse psychosocial outcomes. Here, we quantify the strength of association and estimate effect size (ES) of response inhibition by pooling available evidence in a meta-analysis. We conducted a systematic review of the literature using Ovid MEDLINE and Ovid EMBASE databases (covering 2001-2019) with a search strategy using combinations of the specific Medical Subject Headings (MeSH) terms 'juvenile myoclonic epilepsy, cognitive impulsivity, response inhibition, Stroop, cognition, personality, traits' using the 'explode' feature where possible. We also searched within references of retrieved articles. We included studies reporting ESs describing established measures of response inhibition in teenage and adult patients with JME. Using the ESs pooled from 16 studies comprising 1047 patients and controls, we found ESs for response inhibition to be homogeneous with a significant moderate mean ES of d = 0.50 (95% confidence interval [CI]: 0.37-0.63). We confirm that reduced response inhibition is a consistently observed homogeneous trait in patients with JME.
Sections du résumé
BACKGROUND
Patients with juvenile myoclonic epilepsy (JME) show evidence of cognitive impulsivity that may be linked to later adverse psychosocial outcomes. Here, we quantify the strength of association and estimate effect size (ES) of response inhibition by pooling available evidence in a meta-analysis.
METHODS
We conducted a systematic review of the literature using Ovid MEDLINE and Ovid EMBASE databases (covering 2001-2019) with a search strategy using combinations of the specific Medical Subject Headings (MeSH) terms 'juvenile myoclonic epilepsy, cognitive impulsivity, response inhibition, Stroop, cognition, personality, traits' using the 'explode' feature where possible. We also searched within references of retrieved articles. We included studies reporting ESs describing established measures of response inhibition in teenage and adult patients with JME.
RESULTS
Using the ESs pooled from 16 studies comprising 1047 patients and controls, we found ESs for response inhibition to be homogeneous with a significant moderate mean ES of d = 0.50 (95% confidence interval [CI]: 0.37-0.63).
CONCLUSIONS
We confirm that reduced response inhibition is a consistently observed homogeneous trait in patients with JME.
Identifiants
pubmed: 32240946
pii: S1525-5050(20)30217-1
doi: 10.1016/j.yebeh.2020.107038
pii:
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
107038Subventions
Organisme : Medical Research Council
ID : MR/N026063/1
Pays : United Kingdom
Organisme : Department of Health
ID : RP-PG-0615-20007
Pays : United Kingdom
Organisme : CIHR
ID : 201503MOP-342469
Pays : Canada
Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of competing interest YH-M, FO, and RR have no disclosures to report. DL has – in the past (2000–2002) – received research grants from Janssen-Cilag, GlaxoSmithKline, Pfizer, and the Netherlands Epilepsy Foundation, to start-up the basic EURAP study in the Netherlands.