Contingency awareness, aging, and the parietal lobe.
Classical conditioning
Consciousness
Memory
fMRI
tDCS
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
12
04
2019
revised:
21
02
2020
accepted:
22
02
2020
pubmed:
4
4
2020
medline:
31
10
2020
entrez:
4
4
2020
Statut:
ppublish
Résumé
Contingency awareness is thought to rely on an intact medial temporal lobe and also appears to be a function of age, as older subjects tend to be less aware. The current investigation used functional magnetic resonance imaging, transcranial direct current stimulation, and eyeblink classical conditioning to study brain processes related to contingency awareness as a function of age. Older adults were significantly less aware of the relationship between the tone-airpuff pairings than younger adults. Greater right parietal functional magnetic resonance imaging activation was associated with higher levels of contingency awareness for younger and older subjects. Cathodal transcranial direct current stimulation over the right parietal lobe led to lower levels of awareness in younger subjects without disrupting conditioned responses. Older adults exhibited hyperactivations in the parietal and medial temporal lobes, despite showing no conditioning deficits. These findings strongly support the idea that the parietal cortex serves as a substrate for contingency awareness and that age-related disruption of this region is sufficient to impair awareness, which may be a manifestation of some form of naturally occurring age-related neglect.
Identifiants
pubmed: 32241582
pii: S0197-4580(20)30057-9
doi: 10.1016/j.neurobiolaging.2020.02.024
pmc: PMC7953809
mid: NIHMS1574216
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
125-135Subventions
Organisme : NIAAA NIH HHS
ID : K01 AA020873
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG021501
Pays : United States
Organisme : NIH HHS
ID : S10 OD021648
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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