Sterile α-motif domain requirement for cellular signaling and survival.
erythropoiesis
hemolytic anemia
protein motif
proto-oncogene c-Kit (c-Kit)
receptor tyrosine kinase
stem cell factor (SCF)
sterile α-motif
sterile α-motif domain containing 14 (SAMD14)
stress
structure–function
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
15 05 2020
15 05 2020
Historique:
received:
15
11
2019
revised:
01
04
2020
pubmed:
4
4
2020
medline:
29
12
2020
entrez:
4
4
2020
Statut:
ppublish
Résumé
Hundreds of sterile α-motif (SAM) domains have predicted structural similarities and are reported to bind proteins, lipids, or RNAs. However, the majority of these domains have not been analyzed functionally. Previously, we demonstrated that a SAM domain-containing protein, SAMD14, promotes SCF/proto-oncogene c-Kit (c-Kit) signaling, erythroid progenitor function, and erythrocyte regeneration. Deletion of a Samd14 enhancer (Samd14-Enh), occupied by GATA2 and SCL/TAL1 transcription factors, reduces SAMD14 expression in bone marrow and spleen and is lethal in a hemolytic anemia mouse model. To rigorously establish whether Samd14-Enh deletion reduces anemia-dependent c-Kit signaling by lowering SAMD14 levels, we developed a genetic rescue assay in murine Samd14-Enh
Identifiants
pubmed: 32241909
pii: S0021-9258(17)48211-1
doi: 10.1074/jbc.RA119.011895
pmc: PMC7242717
doi:
Substances chimiques
Proteins
0
Samd14 protein, mouse
0
Proto-Oncogene Proteins c-kit
EC 2.7.10.1
Banques de données
PDB
['2k4p']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7113-7125Subventions
Organisme : NHLBI NIH HHS
ID : T32 HL007899
Pays : United States
Organisme : NIDDK NIH HHS
ID : R37 DK050107
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK113117
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM121316
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014520
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK050107
Pays : United States
Informations de copyright
© 2020 Ray et al.
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