Characterisation of Peste Des Petits Ruminants Disease in Pastoralist Flocks in Ngorongoro District of Northern Tanzania and Bluetongue Virus Co-Infection.
Animals
Animals, Domestic
Antibodies, Viral
/ blood
Bluetongue
/ diagnosis
Bluetongue virus
/ genetics
Coinfection
/ diagnosis
Diagnosis, Differential
Disease Outbreaks
/ veterinary
Goats
Peste-des-Petits-Ruminants
/ diagnosis
Peste-des-petits-ruminants virus
/ classification
Phylogeny
RNA, Viral
/ genetics
Sheep
Tanzania
/ epidemiology
PPR
differential diagnosis
ethno-veterinary knowledge
goats
outbreak investigation
sheep
surveillance
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
31 03 2020
31 03 2020
Historique:
received:
04
02
2020
revised:
25
03
2020
accepted:
30
03
2020
entrez:
5
4
2020
pubmed:
5
4
2020
medline:
17
2
2021
Statut:
epublish
Résumé
Peste des petits ruminants (PPR) disease was first confirmed in Tanzania in 2008 in sheep and goats in Ngorongoro District, northern Tanzania, and is now endemic in this area. This study aimed to characterise PPR disease in pastoralist small ruminant flocks in Ngorongoro District. During June 2015, 33 PPR-like disease reports were investigated in different parts of the district, using semi-structured interviews, clinical examinations, PPR virus rapid detection test (PPRV-RDT), and laboratory analysis. Ten flocks were confirmed as PPRV infected by PPRV-RDT and/or real-time reverse transcription-polymerase chain reaction (RT-qPCR), and two flocks were co-infected with bluetongue virus (BTV), confirmed by RT-qPCR. Phylogenetic analysis of six partial N gene sequences showed that the PPR viruses clustered with recent lineage III Tanzanian viruses, and grouped with Ugandan, Kenyan and Democratic Republic of Congo isolates. No PPR-like disease was reported in wildlife. There was considerable variation in clinical syndromes between flocks: some showed a full range of PPR signs, while others were predominantly respiratory, diarrhoea, or oro-nasal syndromes, which were associated with different local disease names (
Identifiants
pubmed: 32244509
pii: v12040389
doi: 10.3390/v12040389
pmc: PMC7232183
pii:
doi:
Substances chimiques
Antibodies, Viral
0
RNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007036
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L013657/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L013592/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007037
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007034
Pays : United Kingdom
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