αM-Conotoxin MIIIJ Blocks Nicotinic Acetylcholine Receptors at Neuromuscular Junctions of Frog and Fish.

Action Potentials / drug effects Amino Acid Sequence Animals Conotoxins / chemistry Dose-Response Relationship, Drug Excitatory Postsynaptic Potentials / drug effects Goldfish Mice Muscle, Skeletal / drug effects Neuromuscular Junction / drug effects Nicotinic Antagonists / chemistry Paresis / chemically induced Predatory Behavior / drug effects Protein Binding Receptors, Nicotinic / metabolism Sequence Alignment Species Specificity Xenopus laevis
conotoxin neuromuscular junction nicotinic acetylcholine receptor venom

Journal

Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765

Informations de publication

Date de publication:
21 03 2020
Historique:
received: 22 02 2020
revised: 17 03 2020
accepted: 18 03 2020
entrez: 5 4 2020
pubmed: 5 4 2020
medline: 6 3 2021
Statut: epublish

Résumé

We report the discovery and functional characterization of αM-Conotoxin MIIIJ, a peptide from the venom of the fish-hunting cone snail

Identifiants

DOI: 10.3390/toxins12030197 PMID: 32245200 PMC: PMC7150935
pubmed: 32245200
pii: toxins12030197
doi: 10.3390/toxins12030197
pmc: PMC7150935
pii:
doi:

Substances chimiques

Conotoxins 0
Nicotinic Antagonists 0
Receptors, Nicotinic 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIGMS NIH HHS
ID : P01 GM048677
Pays : United States
Organisme : Velux Foundation
ID : 19063
Pays : International
Organisme : NIH HHS
ID : GM048677
Pays : United States

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Auteurs

Matthew J Rybin (MJ)

Department of Biology, University of Utah, Salt Lake City, UT 84112, USA.
Department of Psychiatry and Behavioral Sciences, University of Miami, Miller School of Medicine, Miami, FL 33136, USA.
ORCID: 0000-0001-8578-0891

Henrik O'Brien (H)

Department of Biology, University of Utah, Salt Lake City, UT 84112, USA.

Iris Bea L Ramiro (IBL)

Department of Biology, University of Utah, Salt Lake City, UT 84112, USA.
Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
ORCID: 0000-0003-3971-3107

Layla Azam (L)

Department of Biology, University of Utah, Salt Lake City, UT 84112, USA.

J Michael McIntosh (JM)

Department of Biology, University of Utah, Salt Lake City, UT 84112, USA.
George E. Whalen Veterans Affairs Medical Center, Salt Lake City, UT 84112, USA.
Department of Psychiatry, University of Utah, Salt Lake City, UT 84112, USA.

Baldomero M Olivera (BM)

Department of Biology, University of Utah, Salt Lake City, UT 84112, USA.

Helena Safavi-Hemami (H)

Department of Biology, University of Utah, Salt Lake City, UT 84112, USA.
Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.
ORCID: 0000-0002-1984-2721

Doju Yoshikami (D)

Department of Biology, University of Utah, Salt Lake City, UT 84112, USA.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Potentiels d'action › αM-Conotoxin MIIIJ Blocks Nicotinic...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › αM-Conotoxin MIIIJ Blocks Nicotinic...
questionsmedicales.fr › Eucaryotes › Animaux › αM-Conotoxin MIIIJ Blocks Nicotinic...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins de mollusque › Conotoxines › αM-Conotoxin MIIIJ Blocks Nicotinic...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › αM-Conotoxin MIIIJ Blocks Nicotinic...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Potentiels synaptiques › Potentiels post-synaptiques excitateurs › αM-Conotoxin MIIIJ Blocks Nicotinic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Carpes (poisson) › Poisson rouge › αM-Conotoxin MIIIJ Blocks Nicotinic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › αM-Conotoxin MIIIJ Blocks Nicotinic...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › αM-Conotoxin MIIIJ Blocks Nicotinic...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Synapse neuro-effectrice › Jonction neuromusculaire › αM-Conotoxin MIIIJ Blocks Nicotinic...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Antagonistes cholinergiques › Antagonistes nicotiniques › αM-Conotoxin MIIIJ Blocks Nicotinic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Parésie › αM-Conotoxin MIIIJ Blocks Nicotinic...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement animal › Acte consommatoire › Comportement prédateur › αM-Conotoxin MIIIJ Blocks Nicotinic...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › αM-Conotoxin MIIIJ Blocks Nicotinic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteurs nicotiniques › αM-Conotoxin MIIIJ Blocks Nicotinic...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Alignement de séquences › αM-Conotoxin MIIIJ Blocks Nicotinic...
questionsmedicales.fr › Phénomènes biologiques › Spécificité d'espèce › αM-Conotoxin MIIIJ Blocks Nicotinic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Amphibiens › Anura › Pipidae › Xenopus › Xenopus laevis › αM-Conotoxin MIIIJ Blocks Nicotinic...