Intranasal epinephrine effects on epinephrine pharmacokinetics and heart rate in a nasal congestion canine model.
Allergy
Anaphylaxis
Epinephrine
Histamine
Intranasal
Nasal congestion
Severe allergy
Vasodilation
Journal
Respiratory research
ISSN: 1465-993X
Titre abrégé: Respir Res
Pays: England
ID NLM: 101090633
Informations de publication
Date de publication:
03 Apr 2020
03 Apr 2020
Historique:
received:
10
12
2019
accepted:
25
03
2020
entrez:
5
4
2020
pubmed:
5
4
2020
medline:
30
1
2021
Statut:
epublish
Résumé
Histamine release and vasodilation during an allergic reaction can alter the pharmacokinetics of drugs administered via the intranasal (IN) route. The current study evaluated the effects of histamine-induced nasal congestion on epinephrine pharmacokinetics and heart rate changes after IN epinephrine. Dogs received 5% histamine or saline IN followed by 4 mg epinephrine IN. Nasal restriction pressure, epinephrine concentration, and heart rate were assessed. Maximum concentration (C In the 12 dogs in this study, nasal congestion occurred at 5-10 min after IN histamine administration versus no nasal congestion after IN saline. After administration of IN epinephrine, IN histamine-mediated nasal congestion was significantly reduced to baseline levels at 60, 80, and 100 min. There were no significant differences in C IN histamine led to more rapid epinephrine absorption and immediately increased heart rate compared with IN saline. IN epinephrine decreased histamine-induced nasal congestion.
Sections du résumé
BACKGROUND
BACKGROUND
Histamine release and vasodilation during an allergic reaction can alter the pharmacokinetics of drugs administered via the intranasal (IN) route. The current study evaluated the effects of histamine-induced nasal congestion on epinephrine pharmacokinetics and heart rate changes after IN epinephrine.
METHODS
METHODS
Dogs received 5% histamine or saline IN followed by 4 mg epinephrine IN. Nasal restriction pressure, epinephrine concentration, and heart rate were assessed. Maximum concentration (C
RESULTS
RESULTS
In the 12 dogs in this study, nasal congestion occurred at 5-10 min after IN histamine administration versus no nasal congestion after IN saline. After administration of IN epinephrine, IN histamine-mediated nasal congestion was significantly reduced to baseline levels at 60, 80, and 100 min. There were no significant differences in C
CONCLUSION
CONCLUSIONS
IN histamine led to more rapid epinephrine absorption and immediately increased heart rate compared with IN saline. IN epinephrine decreased histamine-induced nasal congestion.
Identifiants
pubmed: 32245384
doi: 10.1186/s12931-020-01343-x
pii: 10.1186/s12931-020-01343-x
pmc: PMC7119008
doi:
Substances chimiques
Histamine
820484N8I3
Epinephrine
YKH834O4BH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
78Subventions
Organisme : Bryn Pharma LLC
ID : N.A
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