m
Adenosine
/ analogs & derivatives
Animals
Apoptosis
Biomarkers, Tumor
/ genetics
Cell Proliferation
Colorectal Neoplasms
/ genetics
DNA Methylation
Disease Progression
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Glucose Transporter Type 1
/ genetics
Glycolysis
Hexokinase
/ genetics
Humans
Methyltransferases
/ genetics
Mice
Mice, Nude
Prognosis
RNA-Binding Proteins
/ genetics
Survival Rate
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
Colorectal cancer
GLUT1
Glycolysis
HK2
METTL3
m6A modification
Journal
Molecular cancer
ISSN: 1476-4598
Titre abrégé: Mol Cancer
Pays: England
ID NLM: 101147698
Informations de publication
Date de publication:
03 04 2020
03 04 2020
Historique:
received:
22
11
2019
accepted:
24
03
2020
entrez:
5
4
2020
pubmed:
5
4
2020
medline:
3
2
2021
Statut:
epublish
Résumé
Epigenetic alterations are involved in various aspects of colorectal carcinogenesis. N Transcriptome-sequencing and liquid chromatography-tandem mass spectrometry (LC-MS) were performed to evaluate the correlation between m A strong correlation between METTL3 and METTL3 is a functional and clinical oncogene in CRC. METTL3 stabilizes HK2 and SLC2A1 (GLUT1) expression in CRC through an m
Sections du résumé
BACKGROUND
Epigenetic alterations are involved in various aspects of colorectal carcinogenesis. N
METHODS
Transcriptome-sequencing and liquid chromatography-tandem mass spectrometry (LC-MS) were performed to evaluate the correlation between m
RESULTS
A strong correlation between METTL3 and
CONCLUSIONS
METTL3 is a functional and clinical oncogene in CRC. METTL3 stabilizes HK2 and SLC2A1 (GLUT1) expression in CRC through an m
Identifiants
pubmed: 32245489
doi: 10.1186/s12943-020-01190-w
pii: 10.1186/s12943-020-01190-w
pmc: PMC7118901
doi:
Substances chimiques
Biomarkers, Tumor
0
Glucose Transporter Type 1
0
IGF2BP2 protein, human
0
RNA-Binding Proteins
0
SLC2A1 protein, human
0
N-methyladenosine
CLE6G00625
Methyltransferases
EC 2.1.1.-
METTL3 protein, human
EC 2.1.1.62
HK2 protein, human
EC 2.7.1.1
Hexokinase
EC 2.7.1.1
Adenosine
K72T3FS567
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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