Intravenous sildenafil citrate and post-cardiac surgery acute kidney injury: a double-blind, randomised, placebo-controlled trial.
Acute Kidney Injury
/ prevention & control
Administration, Intravenous
Aged
Aged, 80 and over
Cardiac Surgical Procedures
/ adverse effects
Double-Blind Method
Female
Glucose
/ administration & dosage
Humans
Male
Middle Aged
Phosphodiesterase 5 Inhibitors
/ administration & dosage
Postoperative Complications
/ prevention & control
Sildenafil Citrate
/ administration & dosage
United Kingdom
acute kidney injury
cardiac surgery
cardiopulmonary bypass
phosphodiesterase type 5 inhibitors
renal protection
sildenafil citrate
Journal
British journal of anaesthesia
ISSN: 1471-6771
Titre abrégé: Br J Anaesth
Pays: England
ID NLM: 0372541
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
05
09
2019
revised:
09
12
2019
accepted:
18
01
2020
pubmed:
5
4
2020
medline:
26
6
2020
entrez:
5
4
2020
Statut:
ppublish
Résumé
This study assessed whether i.v. sildenafil citrate prevented acute kidney injury in at-risk patients undergoing cardiac surgery with cardiopulmonary bypass. In a double-blind RCT, adults at increased risk of acute kidney injury undergoing cardiac surgery in a single UK tertiary centre were randomised to receive sildenafil citrate 12.5 mg kg The analysis population comprised eligible randomised patients that underwent valve surgery or combined coronary artery bypass graft and valve surgery, with cardiopulmonary bypass, between May 2015 and June 2018. There were 60 subjects in the sildenafil group and 69 in the placebo control group. The difference between groups in creatinine concentration was not statistically significant (MD: 0.88 μmol L These results do not support the use of i.v. sildenafil citrate for kidney protection in adult cardiac surgery. ISRCTN18386427.
Sections du résumé
BACKGROUND
This study assessed whether i.v. sildenafil citrate prevented acute kidney injury in at-risk patients undergoing cardiac surgery with cardiopulmonary bypass.
METHODS
In a double-blind RCT, adults at increased risk of acute kidney injury undergoing cardiac surgery in a single UK tertiary centre were randomised to receive sildenafil citrate 12.5 mg kg
RESULTS
The analysis population comprised eligible randomised patients that underwent valve surgery or combined coronary artery bypass graft and valve surgery, with cardiopulmonary bypass, between May 2015 and June 2018. There were 60 subjects in the sildenafil group and 69 in the placebo control group. The difference between groups in creatinine concentration was not statistically significant (MD: 0.88 μmol L
CONCLUSIONS
These results do not support the use of i.v. sildenafil citrate for kidney protection in adult cardiac surgery.
CLINICAL TRIAL REGISTRATION
ISRCTN18386427.
Identifiants
pubmed: 32245569
pii: S0007-0912(20)30126-4
doi: 10.1016/j.bja.2020.01.030
pmc: PMC7271663
pii:
doi:
Substances chimiques
Phosphodiesterase 5 Inhibitors
0
Sildenafil Citrate
BW9B0ZE037
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
693-701Subventions
Organisme : British Heart Foundation
ID : CH/12/1/29419
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/13/6/29947
Pays : United Kingdom
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.
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