Survival in patients with multiple primary melanomas: Systematic review and meta-analysis.

Humans Melanoma / mortality Neoplasms, Multiple Primary / mortality Skin Neoplasms / mortality Survival Rate
bias melanoma mortality multiple survival survival analysis

Journal

Journal of the American Academy of Dermatology
ISSN: 1097-6787
Titre abrégé: J Am Acad Dermatol
Pays: United States
ID NLM: 7907132

Informations de publication

Date de publication:
Nov 2020
Historique:
received: 09 12 2019
revised: 09 03 2020
accepted: 24 03 2020
pubmed: 5 4 2020
medline: 10 4 2021
entrez: 5 4 2020
Statut: ppublish

Résumé

The literature surrounding survival of patients with multiple primary melanomas (MPM) yields variable and opposing findings, constrained by statistical challenges. To critically examine the available literature regarding survival of patients with MPM compared with a single primary melanoma and detail statistical methods used. Electronic searches were performed of PubMed, Embase, Web of Science, and Scopus, with cross-checking of references, for the period January 1956 to June 2019. Studies published in English examining survival in patients with multiple melanomas were included. Case studies and small case series were excluded. There were 14 studies eligible for inclusion. Conclusions on survival varied markedly depending on the statistical method used. Four studies that accounted for survival bias by partitioning the survival time were included in the quantitative review, with 3 of these reporting a survival disadvantage for MPM, whereas the fourth showed no difference in survival. The pooled hazard ratio was 1.39 (95% confidence interval, 1.07-1.81) but with significant heterogeneity (I Studies showed significant heterogeneity in methodology. When data were analyzed with robust statistical methods, patients with MPM had a survival disadvantage compared with patients with a single primary melanoma.

Sections du résumé

BACKGROUND BACKGROUND
The literature surrounding survival of patients with multiple primary melanomas (MPM) yields variable and opposing findings, constrained by statistical challenges.
OBJECTIVES OBJECTIVE
To critically examine the available literature regarding survival of patients with MPM compared with a single primary melanoma and detail statistical methods used.
METHODS METHODS
Electronic searches were performed of PubMed, Embase, Web of Science, and Scopus, with cross-checking of references, for the period January 1956 to June 2019. Studies published in English examining survival in patients with multiple melanomas were included. Case studies and small case series were excluded.
RESULTS RESULTS
There were 14 studies eligible for inclusion. Conclusions on survival varied markedly depending on the statistical method used. Four studies that accounted for survival bias by partitioning the survival time were included in the quantitative review, with 3 of these reporting a survival disadvantage for MPM, whereas the fourth showed no difference in survival. The pooled hazard ratio was 1.39 (95% confidence interval, 1.07-1.81) but with significant heterogeneity (I
LIMITATIONS CONCLUSIONS
Studies showed significant heterogeneity in methodology.
CONCLUSION CONCLUSIONS
When data were analyzed with robust statistical methods, patients with MPM had a survival disadvantage compared with patients with a single primary melanoma.

Identifiants

DOI: 10.1016/j.jaad.2020.03.076 PMID: 32246965
pubmed: 32246965
pii: S0190-9622(20)30499-0
doi: 10.1016/j.jaad.2020.03.076
pii:
doi:

Types de publication

Journal Article Meta-Analysis Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1406-1414

Informations de copyright

Copyright © 2020 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

Auteurs

Genevieve Peek (G)

Queensland Skin and Cancer Foundation, Queensland Institute of Dermatology, South-Brisbane, Queensland, Australia.

Catherine M Olsen (CM)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

Peter Baade (P)

Cancer Council Queensland, Brisbane, Queensland, Australia; Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia; School of Mathematical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.

Danny R Youlden (DR)

Cancer Council Queensland, Brisbane, Queensland, Australia; Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia.

Joanne F Aitken (JF)

Cancer Council Queensland, Brisbane, Queensland, Australia; Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia; School of Public Health and Social Work, Queensland University of Technology, Brisbane, Queensland, Australia; School of Public Health, The University of Queensland, Brisbane, Queensland, Australia.

Adele C Green (AC)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Cancer Research UK, Manchester Institute and Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

Kiarash Khosrotehrani (K)

Queensland Skin and Cancer Foundation, Queensland Institute of Dermatology, South-Brisbane, Queensland, Australia; The Diamantina Institute, Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia; The Department of Dermatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia. Electronic address: k.khosrotehrani@uq.edu.au.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Survival in patients with multiple primary...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › Survival in patients with multiple primary...
questionsmedicales.fr › Tumeurs › Tumeurs primitives multiples › Survival in patients with multiple primary...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Tumeurs cutanées › Survival in patients with multiple primary...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Mortalité › Taux de survie › Survival in patients with multiple primary...