Relationship Between Phase Solubility Diagrams and Crystalline Structures During Dissolution of Cimetidine/Cyclodextrin Complex Crystals.
Cimetidine
Cyclodextrin
Dissolution study
Phase-solubility diagrams
Polymorph
Journal
Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
13
11
2019
revised:
05
03
2020
accepted:
18
03
2020
pubmed:
5
4
2020
medline:
22
6
2021
entrez:
5
4
2020
Statut:
ppublish
Résumé
Cyclodextrins (CDs) form complex crystals with drugs and improve physicochemical properties of drugs. However, only few reports have summarized relationships between crystal structures of drug/CD and dissolution behavior. In this study, we developed cimetidine (CIM)/CD complex crystals to achieve sustained drug release and investigated the relationship between the dissolution behavior of CIM/CD complexes and their crystal structures. CIM and 3 types of CDs (α-, β-, and γ-CD) formed a complex crystal when subjected to solvent mixing. The CIM/CD complexes had a highly reduced dissolution rate compared to that of the physical mixture of CIM and CD. β-CD improved the solubility of CIM, whereas γ-CD decreased its solubility. Based on the phase solubility diagram, CIM and α-, β-, and γ-CD indicated A-type positive (A
Identifiants
pubmed: 32246979
pii: S0022-3549(20)30188-X
doi: 10.1016/j.xphs.2020.03.029
pii:
doi:
Substances chimiques
Cyclodextrins
0
Pharmaceutical Preparations
0
Cimetidine
80061L1WGD
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2206-2212Informations de copyright
Copyright © 2020 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.