The unique kind of human artificial chromosome: Bypassing the requirement for repetitive centromere DNA.
CENP-A
Centromere
Chromatin
HAC
HJURP
Journal
Experimental cell research
ISSN: 1090-2422
Titre abrégé: Exp Cell Res
Pays: United States
ID NLM: 0373226
Informations de publication
Date de publication:
15 06 2020
15 06 2020
Historique:
received:
05
12
2019
revised:
23
03
2020
accepted:
25
03
2020
pubmed:
5
4
2020
medline:
1
1
2021
entrez:
5
4
2020
Statut:
ppublish
Résumé
Centromeres are essential components of all eukaryotic chromosomes, including artificial/synthetic ones built in the laboratory. In humans, centromeres are typically located on repetitive α-satellite DNA, and these sequences are the "major ingredient" in first-generation human artificial chromosomes (HACs). Repetitive centromeric sequences present a major challenge for the design of synthetic mammalian chromosomes because they are difficult to synthesize, assemble, and characterize. Additionally, in most eukaryotes, centromeres are defined epigenetically. Here, we review the role of the genetic and epigenetic contributions to establishing centromere identity, highlighting recent work to hijack the epigenetic machinery to initiate centromere identity on a new generation of HACs built without α-satellite DNA. We also discuss the opportunities and challenges in developing useful unique sequence-based HACs.
Identifiants
pubmed: 32246994
pii: S0014-4827(20)30193-2
doi: 10.1016/j.yexcr.2020.111978
pmc: PMC7253334
mid: NIHMS1584522
pii:
doi:
Substances chimiques
Chromosomal Proteins, Non-Histone
0
DNA, Satellite
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111978Subventions
Organisme : NIGMS NIH HHS
ID : F32 GM134558
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM130302
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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