Use of in vitro 3D tissue models in genotoxicity testing: Strategic fit, validation status and way forward. Report of the working group from the 7
3D airway models
Comet assay
DNA damage
In vitro genotoxicity testing
Liver spheroids
Micronucleus test
Reconstructed human skin
Journal
Mutation research. Genetic toxicology and environmental mutagenesis
ISSN: 1879-3592
Titre abrégé: Mutat Res Genet Toxicol Environ Mutagen
Pays: Netherlands
ID NLM: 101632149
Informations de publication
Date de publication:
Historique:
received:
09
01
2020
accepted:
09
01
2020
entrez:
6
4
2020
pubmed:
6
4
2020
medline:
25
4
2020
Statut:
ppublish
Résumé
Use of three-dimensional (3D) tissue equivalents in toxicology has been increasing over the last decade as novel preclinical test systems and as alternatives to animal testing. In the area of genetic toxicology, progress has been made with establishing robust protocols for skin, airway (lung) and liver tissue equivalents. In light of these advancements, a "Use of 3D Tissues in Genotoxicity Testing" working group (WG) met at the 7
Identifiants
pubmed: 32247552
pii: S1383-5718(20)30005-X
doi: 10.1016/j.mrgentox.2020.503135
pii:
doi:
Substances chimiques
Mutagens
0
Types de publication
Congress
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
503135Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.