Shareen H Doak

Affiliations

In Vitro Toxicology Group, Institute of Life Science 1, Swansea University Medical School, Swansea University, Singleton Campus, Swansea, SA2 8PP, UK.

Publications (33)

Multiple-endpoint in vitro carcinogenicity test in human cell line TK6 distinguishes carcinogens from non-carcinogens and highlights mechanisms of action.

Archives of toxicology

Avec: Katherine E Chapman , Eleanor C Wilde , Fiona M Chapman , Jatin R Verma , Ume-Kulsoom Shah , Leanne M Stannard , Anna L Seager , James A Tonkin , M Rowan Brown , Ann T Doherty , George E Johnson , Shareen H Doak , Gareth J S Jenkins

Nanomaterials and Innate Immunity: A Perspective of the Current Status in Nanosafety.

Chemical research in toxicology

Avec: James G Cronin , Nicholas Jones , Catherine A Thornton , Gareth J S Jenkins , Shareen H Doak , Martin J D Clift

Common Considerations for Genotoxicity Assessment of Nanomaterials.

Frontiers in toxicology

Avec: Rosalie K Elespuru , Shareen H Doak , Andrew R Collins , Maria Dusinska , Stefan Pfuhler , Mugimane Manjanatha , Renato Cardoso , Connie L Chen

An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials.

NanoImpact

Avec: Anne Bannuscher , Otmar Schmid , Barbara Drasler , Alain Rohrbasser , Hedwig M Braakhuis , Kirsty Meldrum , Edwin P Zwart , Eric R Gremmer , Barbara Birk , Manuel Rissel , Robert Landsiedel , Elisa Moschini , Stephen J Evans , Pramod Kumar , Sezer Orak , Ali Doryab , Johanna Samulin Erdem , Tommaso Serchi , Rob J Vandebriel , Flemming R Cassee , Shareen H Doak , Alke Petri-Fink , Shanbeh Zienolddiny , Martin J D Clift , Barbara Rothen-Rutishauser

Transferability and reproducibility of exposed air-liquid interface co-culture lung models.

NanoImpact

Avec: Hedwig M Braakhuis , Eric R Gremmer , Anne Bannuscher , Barbara Drasler , Sandeep Keshavan , Barbara Rothen-Rutishauser , Barbara Birk , Andreas Verlohner , Robert Landsiedel , Kirsty Meldrum , Shareen H Doak , Martin J D Clift , Johanna Samulin Erdem , Oda A H Foss , Shanbeh Zienolddiny-Narui , Tommaso Serchi , Elisa Moschini , Pamina Weber , Sabina Burla , Pramod Kumar , Otmar Schmid , Edwin Zwart , Jolanda P Vermeulen , Rob J Vandebriel

Investigating STEAP2 as a potential therapeutic target for the treatment of aggressive prostate cancer.

Cellular and molecular biology (Noisy-le-Grand, France)

Avec: Leia A Jones , Gillian E Conway , Aimy Nguyen-Chi , Stephanie Burnell , Gareth J Jenkins , R Steven Conlan , Shareen H Doak

Governance of advanced materials: Shaping a safe and sustainable future.

NanoImpact

Avec: Monique Groenewold , Eric A J Bleeker , Cornelle W Noorlander , Adriënne J A M Sips , Margriet van der Zee , Robert J Aitken , James H Baker , Martine I Bakker , Evert A Bouman , Shareen H Doak , Damjana Drobne , Verónica I Dumit , Marie-Valentine Florin , Wouter Fransman , Mar M Gonzalez , Elisabeth Heunisch , Panagiotis Isigonis , Nina Jeliazkova , Keld Alstrup Jensen , Thomas Kuhlbusch , Iseult Lynch , Mark Morrison , Andrea Porcari , Isabel Rodríguez-Llopis , Blanca M Pozuelo , Susanne Resch , Arto J Säämänen , Tommaso Serchi , Lya G Soeteman-Hernandez , Egon Willighagen , Maria Dusinska , Janeck J Scott-Fordsmand

Optimization of micelle-encapsulated extremely small sized iron oxide nanoparticles as a T1 contrast imaging agent: biodistribution and safety profile.

Journal of nanobiotechnology

Avec: Minseok Suh , Ji Yong Park , Guen Bae Ko , Ji Yoon Kim , Do Won Hwang , Louis Rees , Gillian E Conway , Shareen H Doak , Hyelim Kang , Nohyun Lee , Taeghwan Hyeon , Yun-Sang Lee , Dong Soo Lee

Simulating Nanomaterial Transformation in Cascaded Biological Compartments to Enhance the Physiological Relevance of In Vitro Dosing Regimes: Optional or Required?

Small (Weinheim an der Bergstrasse, Germany)

Avec: Samantha V Llewellyn , Angela Kämpfer , Johannes G Keller , Klaus Vilsmeier , Veronika Büttner , Didem Ag Seleci , Roel P F Schins , Shareen H Doak , Wendel Wohlleben

The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability-A PATROLS Perspective on New Approach Methodologies.

Small (Weinheim an der Bergstrasse, Germany)

Avec: Shareen H Doak , Martin J D Clift , Anna Costa , Christiaan Delmaar , Ilse Gosens , Sabina Halappanavar , Sean Kelly , Willie J G M Pejinenburg , Barbara Rothen-Rutishauser , Roel P F Schins , Vicki Stone , Lang Tran , Martina G Vijver , Ulla Vogel , Wendel Wohlleben , Flemming R Cassee

Alternative lung cell model systems for toxicology testing strategies: Current knowledge and future outlook.

Seminars in cell & developmental biology

Avec: Joana A Moura , Kirsty Meldrum , Shareen H Doak , Martin J D Clift

Current status and future challenges of genotoxicity OECD Test Guidelines for nanomaterials: a workshop report.

Mutagenesis

Avec: Shareen H Doak , Cristina Andreoli , Michael J Burgum , Qasim Chaudhry , Eric A J Bleeker , Cecilia Bossa , Josefa Domenech , Damjana Drobne , Valérie Fessard , Nina Jeliazkova , Eleonora Longhin , Elise Rundén-Pran , Maciej Stępnik , Naouale El Yamani , Julia Catalán , Maria Dusinska

A template wizard for the cocreation of machine-readable data-reporting to harmonize the evaluation of (nano)materials.

Nature protocols

Avec: Nina Jeliazkova , Eleonora Longhin , Naouale El Yamani , Elise Rundén-Pran , Elisa Moschini , Tommaso Serchi , Ivana Vinković Vrček , Michael J Burgum , Shareen H Doak , Mihaela Roxana Cimpan , Ivan Rios-Mondragon , Emil Cimpan , Chiara L Battistelli , Cecilia Bossa , Rositsa Tsekovska , Damjana Drobne , Sara Novak , Neža Repar , Ammar Ammar , Penny Nymark , Veronica Di Battista , Anita Sosnowska , Tomasz Puzyn , Nikolay Kochev , Luchesar Iliev , Vedrin Jeliazkov , Katie Reilly , Iseult Lynch , Martine Bakker , Camila Delpivo , Araceli Sánchez Jiménez , Ana Sofia Fonseca , Nicolas Manier , María Luisa Fernandez-Cruz , Shahzad Rashid , Egon Willighagen , Margarita D Apostolova , Maria Dusinska

Nasoseptal chondroprogenitors isolated through fibronectin-adherence confer no biological advantage for cartilage tissue engineering compared to nasoseptal chondrocytes.

Frontiers in bioengineering and biotechnology

Avec: Thomas H Jovic , Emman J Thomson , Nick Jones , Catherine A Thornton , Shareen H Doak , Iain S Whitaker

Inter-laboratory variability of A549 epithelial cells grown under submerged and air-liquid interface conditions.

Toxicology in vitro : an international journal published in association with BIBRA

Avec: Hana Barosova , Kirsty Meldrum , Bedia Begum Karakocak , Sandor Balog , Shareen H Doak , Alke Petri-Fink , Martin J D Clift , Barbara Rothen-Rutishauser

The effect of chronic dosing and p53 status on the genotoxicity of pro-oxidant chemicals in vitro.

Mutagenesis

Avec: Emrah Dural , Ume-Kulsoom Shah , Demi Pritchard , Katherine Emma Chapman , Shareen Heather Doak , Gareth James Scott Jenkins

Horizon scanning for novel and emerging in vitro mammalian cell mutagenicity test systems.

Mutation research. Genetic toxicology and environmental mutagenesis

Avec: Stephen J Evans , Bhaskar Gollapudi , Martha M Moore , Shareen H Doak

Utilisation of the STEAP protein family in a diagnostic setting may provide a more comprehensive prognosis of prostate cancer.

PloS one

Avec: Stephanie E A Burnell , Samantha Spencer-Harty , Suzie Howarth , Owen Bodger , Howard Kynaston , Claire Morgan , Shareen H Doak

In vitro detection of in vitro secondary mechanisms of genotoxicity induced by engineered nanomaterials.

Particle and fibre toxicology

Avec: Stephen J Evans , Martin J D Clift , Neenu Singh , John W Wills , Nicole Hondow , Thomas S Wilkinson , Michael J Burgum , Andy P Brown , Gareth J Jenkins , Shareen H Doak

An Alternative Perspective towards Reducing the Risk of Engineered Nanomaterials to Human Health.

Small (Weinheim an der Bergstrasse, Germany)

Avec: Martin J D Clift , Gareth J S Jenkins , Shareen H Doak

Use of in vitro 3D tissue models in genotoxicity testing: Strategic fit, validation status and way forward. Report of the working group from the 7

Mutation research. Genetic toxicology and environmental mutagenesis

Avec: Stefan Pfuhler , Jan van Benthem , Rodger Curren , Shareen H Doak , Maria Dusinska , Makoto Hayashi , Robert H Heflich , Darren Kidd , David Kirkland , Yang Luan , Gladys Ouedraogo , Kerstin Reisinger , Toshio Sofuni , Frédérique van Acker , Ying Yang , Raffaella Corvi

Understanding the impact of more realistic low-dose, prolonged engineered nanomaterial exposure on genotoxicity using 3D models of the human liver.

Journal of nanobiotechnology

Avec: Samantha V Llewellyn , Gillian E Conway , Ilaria Zanoni , Amalie Kofoed Jørgensen , Ume-Kulsoom Shah , Didem Ag Seleci , Johannes G Keller , Jeong Won Kim , Wendel Wohlleben , Keld Alstrup Jensen , Anna Costa , Gareth J S Jenkins , Martin J D Clift , Shareen H Doak

In vitro and integrated in vivo strategies to reduce animal use in genotoxicity testing.

Mutagenesis

Avec: Katherine Groff , Stephen J Evans , Shareen H Doak , Stefan Pfuhler , Raffaella Corvi , Samantha Saunders , Gilly Stoddart

Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids.

Toxicology in vitro : an international journal published in association with BIBRA

Avec: Samantha V Llewellyn , Ali Kermanizadeh , Victor Ude , Nicklas Raun Jacobsen , Gillian E Conway , Ume-Kulsoom Shah , Marije Niemeijer , Martijn J Moné , Bob van de Water , Shambhu Roy , Wolfgang Moritz , Vicki Stone , Gareth J S Jenkins , Shareen H Doak

The miniaturized enzyme-modified comet assay for genotoxicity testing of nanomaterials.

Frontiers in toxicology

Avec: N El Yamani , E Rundén-Pran , A R Collins , E M Longhin , E Elje , P Hoet , I Vinković Vrček , S H Doak , V Fessard , M Dusinska

An In Vitro Model to Assess Early Immune Markers Following Co-Exposure of Epithelial Cells to Carbon Black (Nano)Particles in the Presence of

Biomedicines

Avec: Scott Brown , Stephen J Evans , Michael J Burgum , Kirsty Meldrum , Jack Herridge , Blessing Akinbola , Llinos G Harris , Rowena Jenkins , Shareen H Doak , Martin J D Clift , Thomas S Wilkinson

Exploring the Role of Fibrin Gels in Enhancing Cell Migration for Vasculature Formation.

Journal of functional biomaterials

Avec: Joana A Moura , Hugh J Barlow , Shareen H Doak , Karl Hawkins , Iris Muller , Martin J D Clift

Adaptation of the in vitro micronucleus assay for genotoxicity testing using 3D liver models supporting longer-term exposure durations.

Mutagenesis

Avec: Gillian E Conway , Ume-Kulsoom Shah , Samantha Llewellyn , Tereza Cervena , Stephen J Evans , Abdullah S Al Ali , Gareth J Jenkins , Martin J D Clift , Shareen H Doak

In Vitro Primary-Indirect Genotoxicity in Bronchial Epithelial Cells Promoted by Industrially Relevant Few-Layer Graphene.

Small (Weinheim an der Bergstrasse, Germany)

Avec: Michael J Burgum , Martin J D Clift , Stephen J Evans , Nicole Hondow , Mark Miller , Sandra Bustamante Lopez , Adam Williams , Afshin Tarat , Gareth J Jenkins , Shareen H Doak

Detection of urethane-induced genotoxicity in vitro using metabolically competent human 2D and 3D spheroid culture models.

Mutagenesis

Avec: Ume-Kulsoom Shah , Jatin R Verma , Katherine E Chapman , Eleanor C Wilde , James A Tonkin , Martyn R Brown , George E Johnson , Shareen H Doak , Gareth J Jenkins

In Vitro Three-Dimensional Liver Models for Nanomaterial DNA Damage Assessment.

Small (Weinheim an der Bergstrasse, Germany)

Avec: Samantha V Llewellyn , Marije Niemeijer , Penny Nymark , Martijn J Moné , Bob van de Water , Gillian E Conway , Gareth J S Jenkins , Shareen H Doak

Deducing the cellular mechanisms associated with the potential genotoxic impact of gold and silver engineered nanoparticles upon different lung epithelial cell lines

Nanotoxicology

Avec: Samantha V Llewellyn , Wolfgang J Parak , Jonas Hühn , Michael J Burgum , Stephen J Evans , Katherine E Chapman , Gareth J S Jenkins , Shareen H Doak , Martin J D Clift

A systematic quality evaluation and review of nanomaterial genotoxicity studies: a regulatory perspective.

Particle and fibre toxicology

Avec: Kirsi M Siivola , Michael J Burgum , Blanca Suárez-Merino , Martin J D Clift , Shareen H Doak , Julia Catalán

Réseau de co-auteurs

Martin J D Clift 15 collaborations

Stephen J Evans 8 collaborations

Gareth J S Jenkins 7 collaborations

Michael J Burgum 7 collaborations

Ume-Kulsoom Shah 6 collaborations

Gillian E Conway 6 collaborations

Maria Dusinska 5 collaborations

Kirsty Meldrum 5 collaborations

Gareth J Jenkins 5 collaborations

Samantha V Llewellyn 5 collaborations

Tommaso Serchi 4 collaborations

Barbara Rothen-Rutishauser 4 collaborations

Katherine E Chapman 3 collaborations

Stefan Pfuhler 3 collaborations

Elisa Moschini 3 collaborations

Damjana Drobne 3 collaborations

Nina Jeliazkova 3 collaborations

Wendel Wohlleben 3 collaborations

Eleanor C Wilde 2 collaborations

Jatin R Verma 2 collaborations

James A Tonkin 2 collaborations

George E Johnson 2 collaborations

Catherine A Thornton 2 collaborations

Anne Bannuscher 2 collaborations

Otmar Schmid 2 collaborations

Barbara Drasler 2 collaborations

Hedwig M Braakhuis 2 collaborations

Eric R Gremmer 2 collaborations

Barbara Birk 2 collaborations

Robert Landsiedel 2 collaborations

Pramod Kumar 2 collaborations

Johanna Samulin Erdem 2 collaborations

Rob J Vandebriel 2 collaborations

Flemming R Cassee 2 collaborations

Alke Petri-Fink 2 collaborations

Eric A J Bleeker 2 collaborations

Keld Alstrup Jensen 2 collaborations

Iseult Lynch 2 collaborations

Egon Willighagen 2 collaborations

Johannes G Keller 2 collaborations

Didem Ag Seleci 2 collaborations

Roel P F Schins 2 collaborations

Anna Costa 2 collaborations

Vicki Stone 2 collaborations

Joana A Moura 2 collaborations

Cecilia Bossa 2 collaborations

Eleonora Longhin 2 collaborations

Elise Rundén-Pran 2 collaborations

Naouale El Yamani 2 collaborations

Julia Catalán 2 collaborations

Penny Nymark 2 collaborations

Nicole Hondow 2 collaborations

Thomas S Wilkinson 2 collaborations

Raffaella Corvi 2 collaborations

Marije Niemeijer 2 collaborations

Martijn J Moné 2 collaborations

Bob van de Water 2 collaborations

Fiona M Chapman 1 collaboration

Leanne M Stannard 1 collaboration

Anna L Seager 1 collaboration

M Rowan Brown 1 collaboration

Ann T Doherty 1 collaboration

James G Cronin 1 collaboration

Nicholas Jones 1 collaboration

Rosalie K Elespuru 1 collaboration

Andrew R Collins 1 collaboration

Mugimane Manjanatha 1 collaboration

Renato Cardoso 1 collaboration

Connie L Chen 1 collaboration

Alain Rohrbasser 1 collaboration

Edwin P Zwart 1 collaboration

Manuel Rissel 1 collaboration

Sezer Orak 1 collaboration

Ali Doryab 1 collaboration

Shanbeh Zienolddiny 1 collaboration

Sandeep Keshavan 1 collaboration

Andreas Verlohner 1 collaboration

Oda A H Foss 1 collaboration

Shanbeh Zienolddiny-Narui 1 collaboration

Pamina Weber 1 collaboration

Sabina Burla 1 collaboration

Edwin Zwart 1 collaboration

Jolanda P Vermeulen 1 collaboration

Leia A Jones 1 collaboration

Aimy Nguyen-Chi 1 collaboration

Stephanie Burnell 1 collaboration

R Steven Conlan 1 collaboration

Monique Groenewold 1 collaboration

Cornelle W Noorlander 1 collaboration

Adriënne J A M Sips 1 collaboration

Margriet van der Zee 1 collaboration

Robert J Aitken 1 collaboration

James H Baker 1 collaboration

Martine I Bakker 1 collaboration

Evert A Bouman 1 collaboration

Verónica I Dumit 1 collaboration

Marie-Valentine Florin 1 collaboration

Wouter Fransman 1 collaboration

Mar M Gonzalez 1 collaboration

Elisabeth Heunisch 1 collaboration

Panagiotis Isigonis 1 collaboration

Thomas Kuhlbusch 1 collaboration

Mark Morrison 1 collaboration

Andrea Porcari 1 collaboration

Isabel Rodríguez-Llopis 1 collaboration

Blanca M Pozuelo 1 collaboration

Susanne Resch 1 collaboration

Arto J Säämänen 1 collaboration

Lya G Soeteman-Hernandez 1 collaboration

Janeck J Scott-Fordsmand 1 collaboration

Minseok Suh 1 collaboration

Ji Yong Park 1 collaboration

Guen Bae Ko 1 collaboration

Ji Yoon Kim 1 collaboration

Do Won Hwang 1 collaboration

Louis Rees 1 collaboration

Hyelim Kang 1 collaboration

Nohyun Lee 1 collaboration

Taeghwan Hyeon 1 collaboration

Yun-Sang Lee 1 collaboration

Dong Soo Lee 1 collaboration

Angela Kämpfer 1 collaboration

Klaus Vilsmeier 1 collaboration

Veronika Büttner 1 collaboration

Christiaan Delmaar 1 collaboration

Ilse Gosens 1 collaboration

Sabina Halappanavar 1 collaboration

Sean Kelly 1 collaboration

Willie J G M Pejinenburg 1 collaboration

Lang Tran 1 collaboration

Martina G Vijver 1 collaboration

Ulla Vogel 1 collaboration

Cristina Andreoli 1 collaboration

Qasim Chaudhry 1 collaboration

Josefa Domenech 1 collaboration

Valérie Fessard 1 collaboration

Maciej Stępnik 1 collaboration

Ivana Vinković Vrček 1 collaboration

Mihaela Roxana Cimpan 1 collaboration

Ivan Rios-Mondragon 1 collaboration

Emil Cimpan 1 collaboration

Chiara L Battistelli 1 collaboration

Rositsa Tsekovska 1 collaboration

Sara Novak 1 collaboration

Neža Repar 1 collaboration

Ammar Ammar 1 collaboration

Veronica Di Battista 1 collaboration

Anita Sosnowska 1 collaboration

Tomasz Puzyn 1 collaboration

Nikolay Kochev 1 collaboration

Luchesar Iliev 1 collaboration

Vedrin Jeliazkov 1 collaboration

Katie Reilly 1 collaboration

Martine Bakker 1 collaboration

Camila Delpivo 1 collaboration

Araceli Sánchez Jiménez 1 collaboration

Ana Sofia Fonseca 1 collaboration

Nicolas Manier 1 collaboration

María Luisa Fernandez-Cruz 1 collaboration

Shahzad Rashid 1 collaboration

Margarita D Apostolova 1 collaboration

Thomas H Jovic 1 collaboration

Emman J Thomson 1 collaboration

Nick Jones 1 collaboration

Iain S Whitaker 1 collaboration

Hana Barosova 1 collaboration

Bedia Begum Karakocak 1 collaboration

Sandor Balog 1 collaboration

Emrah Dural 1 collaboration

Demi Pritchard 1 collaboration

Katherine Emma Chapman 1 collaboration

Shareen Heather Doak 1 collaboration

Gareth James Scott Jenkins 1 collaboration

Bhaskar Gollapudi 1 collaboration

Martha M Moore 1 collaboration

Stephanie E A Burnell 1 collaboration

Samantha Spencer-Harty 1 collaboration

Suzie Howarth 1 collaboration

Owen Bodger 1 collaboration

Howard Kynaston 1 collaboration

Claire Morgan 1 collaboration

Neenu Singh 1 collaboration

John W Wills 1 collaboration

Andy P Brown 1 collaboration

Jan van Benthem 1 collaboration

Rodger Curren 1 collaboration

Makoto Hayashi 1 collaboration

Robert H Heflich 1 collaboration

Darren Kidd 1 collaboration

David Kirkland 1 collaboration

Yang Luan 1 collaboration

Gladys Ouedraogo 1 collaboration

Kerstin Reisinger 1 collaboration

Toshio Sofuni 1 collaboration

Frédérique van Acker 1 collaboration

Ying Yang 1 collaboration

Ilaria Zanoni 1 collaboration

Amalie Kofoed Jørgensen 1 collaboration

Jeong Won Kim 1 collaboration

Katherine Groff 1 collaboration

Samantha Saunders 1 collaboration

Gilly Stoddart 1 collaboration

Ali Kermanizadeh 1 collaboration

Victor Ude 1 collaboration

Nicklas Raun Jacobsen 1 collaboration

Shambhu Roy 1 collaboration

Wolfgang Moritz 1 collaboration

N El Yamani 1 collaboration

E Rundén-Pran 1 collaboration

A R Collins 1 collaboration

E M Longhin 1 collaboration

E Elje 1 collaboration

P Hoet 1 collaboration

I Vinković Vrček 1 collaboration

S H Doak 1 collaboration

V Fessard 1 collaboration

M Dusinska 1 collaboration

Scott Brown 1 collaboration

Jack Herridge 1 collaboration

Blessing Akinbola 1 collaboration

Llinos G Harris 1 collaboration

Rowena Jenkins 1 collaboration

Hugh J Barlow 1 collaboration

Karl Hawkins 1 collaboration

Iris Muller 1 collaboration

Samantha Llewellyn 1 collaboration

Tereza Cervena 1 collaboration

Abdullah S Al Ali 1 collaboration

Mark Miller 1 collaboration

Sandra Bustamante Lopez 1 collaboration

Adam Williams 1 collaboration

Afshin Tarat 1 collaboration

Martyn R Brown 1 collaboration

Wolfgang J Parak 1 collaboration

Jonas Hühn 1 collaboration

Kirsi M Siivola 1 collaboration

Blanca Suárez-Merino 1 collaboration