An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials.

Fluorescein Correlation of Data Upper Extremity
Aerosol-cell exposure DQ(12) Inter-laboratory comparison Nanomaterials Nanoparticles Standard operating procedure (SOP) TiO(2) NM-105 VITROCELL® Cloud12 system

Journal

NanoImpact
ISSN: 2452-0748
Titre abrégé: NanoImpact
Pays: Netherlands
ID NLM: 101676795

Informations de publication

Date de publication:
10 2022
Historique:
received: 19 08 2022
revised: 13 11 2022
accepted: 14 11 2022
pubmed: 20 11 2022
medline: 15 12 2022
entrez: 19 11 2022
Statut: ppublish

Résumé

Air-liquid interface (ALI) lung cell models cultured on permeable transwell inserts are increasingly used for respiratory hazard assessment requiring controlled aerosolization and deposition of any material on ALI cells. The approach presented herein aimed to assess the transwell insert-delivered dose of aerosolized materials using the VITROCELL® Cloud12 system, a commercially available aerosol-cell exposure system. An inter-laboratory comparison study was conducted with seven European partners having different levels of experience with the VITROCELL® Cloud12. A standard operating procedure (SOP) was developed and applied by all partners for aerosolized delivery of materials, i.e., a water-soluble molecular substance (fluorescence-spiked salt) and two poorly soluble particles, crystalline silica quartz (DQ

Identifiants

DOI: 10.1016/j.impact.2022.100439 PMID: 36402283
pubmed: 36402283
pii: S2452-0748(22)00061-1
doi: 10.1016/j.impact.2022.100439
pii:
doi:

Substances chimiques

Fluorescein TPY09G7XIR

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

100439

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Barbara Birk, Manuel Rissel, Robert Landsiedel are employees of BASF. BASF produces some of the test material. In the future this set-up (Cloud12) might be used also for toxicological testing of BASF products. Otmar Schmid is employee of the Helmholtz Zentrum Munich, which receives license fees for the VITROCELL Cloud technology. Otmar Schmid as co-patent holder of the underlying ALICE Cloud technology receives a share of these license fees. All other authors declare no competing financial interests.

Auteurs

Anne Bannuscher (A)

Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, 1700 Fribourg, Switzerland.

Otmar Schmid (O)

Comprehensive Pneumology Center (CPC-M), Helmholtz Zentrum München - Member of the German Center for Lung Research (DZL), Max-Lebsche-Platz 31, 81377 Munich, Germany; Institute of Lung Health and Immunity, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.

Barbara Drasler (B)

Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, 1700 Fribourg, Switzerland.

Alain Rohrbasser (A)

Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, 1700 Fribourg, Switzerland.

Hedwig M Braakhuis (HM)

National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720, BA, Bilthoven, the Netherlands.

Kirsty Meldrum (K)

In Vitro Toxicology Group, Faculty of Medicine, Health and Life Sciences, Medical School, Institute of Life Sciences, Centre for NanoHealth, Swansea University, Singleton Campus, Wales SA2 8PP, UK.

Edwin P Zwart (EP)

National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720, BA, Bilthoven, the Netherlands.

Eric R Gremmer (ER)

National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720, BA, Bilthoven, the Netherlands.

Barbara Birk (B)

BASF SE, Experimental Toxicology and Ecology, 67056 Ludwigshafen am Rhein, Germany.

Manuel Rissel (M)

BASF SE, Experimental Toxicology and Ecology, 67056 Ludwigshafen am Rhein, Germany.

Robert Landsiedel (R)

BASF SE, Experimental Toxicology and Ecology, 67056 Ludwigshafen am Rhein, Germany; Free University of Berlin, Pharmacy, Pharmacology and Toxicology, 14195 Berlin, Germany.

Elisa Moschini (E)

Department of Environmental Research and Innovation, Luxembourg Institute of Science and Technology (LIST), 41 rue du Brill, L4422 Belvaux, Grand-Duchy of Luxembourg, Luxembourg.

Stephen J Evans (SJ)

In Vitro Toxicology Group, Faculty of Medicine, Health and Life Sciences, Medical School, Institute of Life Sciences, Centre for NanoHealth, Swansea University, Singleton Campus, Wales SA2 8PP, UK.

Pramod Kumar (P)

Comprehensive Pneumology Center (CPC-M), Helmholtz Zentrum München - Member of the German Center for Lung Research (DZL), Max-Lebsche-Platz 31, 81377 Munich, Germany; Institute of Lung Health and Immunity, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.

Sezer Orak (S)

Comprehensive Pneumology Center (CPC-M), Helmholtz Zentrum München - Member of the German Center for Lung Research (DZL), Max-Lebsche-Platz 31, 81377 Munich, Germany; Institute of Lung Health and Immunity, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.

Ali Doryab (A)

Comprehensive Pneumology Center (CPC-M), Helmholtz Zentrum München - Member of the German Center for Lung Research (DZL), Max-Lebsche-Platz 31, 81377 Munich, Germany; Institute of Lung Health and Immunity, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.

Johanna Samulin Erdem (JS)

National Institute of Occupational Health (STAMI), N-0033 Oslo, Norway.

Tommaso Serchi (T)

Department of Environmental Research and Innovation, Luxembourg Institute of Science and Technology (LIST), 41 rue du Brill, L4422 Belvaux, Grand-Duchy of Luxembourg, Luxembourg.

Rob J Vandebriel (RJ)

National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720, BA, Bilthoven, the Netherlands.

Flemming R Cassee (FR)

National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720, BA, Bilthoven, the Netherlands; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.

Shareen H Doak (SH)

In Vitro Toxicology Group, Faculty of Medicine, Health and Life Sciences, Medical School, Institute of Life Sciences, Centre for NanoHealth, Swansea University, Singleton Campus, Wales SA2 8PP, UK.

Alke Petri-Fink (A)

Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, 1700 Fribourg, Switzerland.

Shanbeh Zienolddiny (S)

National Institute of Occupational Health (STAMI), N-0033 Oslo, Norway.

Martin J D Clift (MJD)

In Vitro Toxicology Group, Faculty of Medicine, Health and Life Sciences, Medical School, Institute of Life Sciences, Centre for NanoHealth, Swansea University, Singleton Campus, Wales SA2 8PP, UK.

Barbara Rothen-Rutishauser (B)

Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, 1700 Fribourg, Switzerland. Electronic address: barbara.rothen@unifr.ch.

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Classifications MeSH

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