The cardiac isovolumetric contraction time is an independent predictor of incident heart failure in the general population.
Cardiac time intervals
Echocardiography
General population
Heart failure
Long-term outcome
Prognostic
Journal
International journal of cardiology
ISSN: 1874-1754
Titre abrégé: Int J Cardiol
Pays: Netherlands
ID NLM: 8200291
Informations de publication
Date de publication:
01 08 2020
01 08 2020
Historique:
received:
19
11
2019
revised:
29
02
2020
accepted:
18
03
2020
pubmed:
6
4
2020
medline:
15
5
2021
entrez:
6
4
2020
Statut:
ppublish
Résumé
Color Tissue Doppler imaging (TDI) M-mode through the mitral leaflet is a novel method to obtain the cardiac time intervals including the isovolumic contraction time (IVCT), isovolumic relaxation time (IVRT) and ejection time (ET). The myocardial performance index (MPI) is defined as [(IVCT+IVRT)/ET]. Our aim was to investigate if the cardiac time intervals can be used to predict heart failure (HF) in the general population. A total of 1915 participants (mean age 58 ± 16 years, 42% male) from the general population (The Copenhagen City Heart Study) underwent a health examination including TDI-echocardiography. The primary endpoint was incident HF. Participants with a history of HF were excluded (n = 23). During a median follow-up time of 16 years, 172 (9%) participants were diagnosed with incident HF. The risk of HF increased with 24% per 10 ms increase in IVCT (per 10 ms increase: HR 1.24; 95%CI (1.14-1.36), p < 0.001). The association remained significant after adjusting for age, sex, hypertension, diabetes, previous ischemic heart disease, diastolic blood pressure, heart rate, body mass index, eGFR, proBNP, LVEF <50%, s', LAVI, and E/e' (per 10 ms increase: HR 1.13; 95% CI (1.00-1.27), p = 0.045). A significant association was found between MPI and HF both in unadjusted and adjusted models (per 0.1 increase: HR 6.93; 95% CI (1.63-29.31), p = 0.009). No associations between the IVRT or ET and HF remained significant after multivariable adjustment. In the general population the IVCT provides novel and independent prognostic information on the long-term risk of incident HF.
Sections du résumé
BACKGROUND
Color Tissue Doppler imaging (TDI) M-mode through the mitral leaflet is a novel method to obtain the cardiac time intervals including the isovolumic contraction time (IVCT), isovolumic relaxation time (IVRT) and ejection time (ET). The myocardial performance index (MPI) is defined as [(IVCT+IVRT)/ET]. Our aim was to investigate if the cardiac time intervals can be used to predict heart failure (HF) in the general population.
METHODS AND RESULTS
A total of 1915 participants (mean age 58 ± 16 years, 42% male) from the general population (The Copenhagen City Heart Study) underwent a health examination including TDI-echocardiography. The primary endpoint was incident HF. Participants with a history of HF were excluded (n = 23). During a median follow-up time of 16 years, 172 (9%) participants were diagnosed with incident HF. The risk of HF increased with 24% per 10 ms increase in IVCT (per 10 ms increase: HR 1.24; 95%CI (1.14-1.36), p < 0.001). The association remained significant after adjusting for age, sex, hypertension, diabetes, previous ischemic heart disease, diastolic blood pressure, heart rate, body mass index, eGFR, proBNP, LVEF <50%, s', LAVI, and E/e' (per 10 ms increase: HR 1.13; 95% CI (1.00-1.27), p = 0.045). A significant association was found between MPI and HF both in unadjusted and adjusted models (per 0.1 increase: HR 6.93; 95% CI (1.63-29.31), p = 0.009). No associations between the IVRT or ET and HF remained significant after multivariable adjustment.
CONCLUSION
In the general population the IVCT provides novel and independent prognostic information on the long-term risk of incident HF.
Identifiants
pubmed: 32247573
pii: S0167-5273(19)35169-1
doi: 10.1016/j.ijcard.2020.03.046
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
81-86Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors report no relationships that could be construed as a conflict of interest.