Predictive Models for Pulmonary Artery Size in Fontan Patients.
Adolescent
Adult
Age Factors
Body Surface Area
Child
Child, Preschool
Female
Fontan Procedure
/ adverse effects
Hemodynamics
Humans
Magnetic Resonance Angiography
Male
Models, Anatomic
Models, Cardiovascular
Patient-Specific Modeling
Predictive Value of Tests
Pulmonary Artery
/ diagnostic imaging
Pulmonary Circulation
Retrospective Studies
Treatment Outcome
Univentricular Heart
/ diagnostic imaging
Young Adult
Fontan geometry
Predictive models
Pulmonary artery index
Regression analysis
Univentricular physiology
Journal
Journal of cardiovascular translational research
ISSN: 1937-5395
Titre abrégé: J Cardiovasc Transl Res
Pays: United States
ID NLM: 101468585
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
16
01
2020
accepted:
18
03
2020
pubmed:
6
4
2020
medline:
3
2
2022
entrez:
6
4
2020
Statut:
ppublish
Résumé
We developed models of pulmonary artery (PA) size in Fontan patients as a function of age and body surface area (BSA) using linear regression and breakpoint analyses based on data from 43 Fontan patients divided into two groups: the extracardiac conduit (ECC) group (n = 24) and the non-ECC group (n = 19). Model predictions were compared against those of a non-Fontan control group (n = 18) and published literature. We observed strong positive correlations of the mean PA diameter with BSA (r = 0.9, p < 0.05) and age (r = 0.88, p < 0.05) in the ECC group. The absolute percentage differences between our BSA and age model predictions against published literature were less than 16% and 20%, respectively. Predicted PA size for Fontan patients was consistently smaller than the control group. These models may serve as useful references for clinicians and be utilized to construct 3D anatomic models that correspond to patient body size or age.
Identifiants
pubmed: 32248348
doi: 10.1007/s12265-020-09993-4
pii: 10.1007/s12265-020-09993-4
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
782-789Subventions
Organisme : American Heart Association-American Stroke Association
ID : 16SDG29850012
Pays : United States
Informations de copyright
© 2020. Springer Science+Business Media, LLC, part of Springer Nature.
Références
de Zélicourt, D. A., & Kurtcuoglu, V. (2016). Patient-specific surgical planning, where do we stand? The example of the Fontan procedure. Annals of Biomedical Engineering, 44(1), 174–186. https://doi.org/10.1007/s10439-015-1381-9 .
doi: 10.1007/s10439-015-1381-9
pubmed: 26183962
Bossers, S. S. M., Cibis, M., Gijsen, F. J., Schokking, M., Strengers, J. L. M., Verhaart, R. F., et al. (2014). Computational fluid dynamics in Fontan patients to evaluate power loss during simulated exercise. Heart (British Cardiac Society), 100(9), 696–701. https://doi.org/10.1136/heartjnl-2013-304969 .
doi: 10.1136/heartjnl-2013-304969
Tang, E., Wei, Z. (. A.)., Whitehead, K. K., Khiabani, R. H., Restrepo, M., Mirabella, L., et al. (2017). Effect of Fontan geometry on exercise haemodynamics and its potential implications. Heart, 103(22), 1806–1812. https://doi.org/10.1136/heartjnl-2016-310855 .
Khiabani, R. H., Whitehead, K. K., Han, D., Restrepo, M., Tang, E., Bethel, J., et al. (2015). Exercise capacity in single-ventricle patients after Fontan correlates with haemodynamic energy loss in TCPC. Heart, 101(2), 139–143. https://doi.org/10.1136/heartjnl-2014-306337 .
doi: 10.1136/heartjnl-2014-306337
pubmed: 25184826
Kung, E., Baretta, A., Baker, C., Arbia, G., Biglino, G., Corsini, C., et al. (2013). Predictive modeling of the virtual hemi-Fontan operation for second stage single ventricle palliation: two patient-specific cases. Journal of Biomechanics, 46(2), 423–429. https://doi.org/10.1016/j.jbiomech.2012.10.023 .
doi: 10.1016/j.jbiomech.2012.10.023
pubmed: 23174419
Baretta, A., Corsini, C., Yang, W., Vignon-Clementel, I. E., Marsden, A. L., Feinstein, J. A., et al. (2011). Virtual surgeries in patients with congenital heart disease: a multi-scale modelling test case. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 369(1954), 4316–4330. https://doi.org/10.1098/rsta.2011.0130 .
doi: 10.1098/rsta.2011.0130
pubmed: 21969678
Marsden, A. L., Bernstein, A. J., Reddy, V. M., Shadden, S. C., Spilker, R. L., Chan, F. P., et al. (2009). Evaluation of a novel Y-shaped extracardiac Fontan baffle using computational fluid dynamics, Journal of Thoracic and Cardiovascular Surgery., 137(2), 394–403.e2. https://doi.org/10.1016/j.jtcvs.2008.06.043 .
Dasi, L. P., KrishnankuttyRema, R., Kitajima, H. D., Pekkan, K., Sundareswaran, K. S., Fogel, M., et al. (2009). Fontan hemodynamics: importance of pulmonary artery diameter. Journal of Thoracic and Cardiovascular Surgery, 137(3), 560–564. https://doi.org/10.1016/j.jtcvs.2008.04.036 .
doi: 10.1016/j.jtcvs.2008.04.036
Tatum, G. H., Sigfússon, G., Ettedgui, J. A., Myers, J. L., Cyran, S. E., Weber, H. S., & Webber, S. A. (2006). Pulmonary artery growth fails to match the increase in body surface area after the Fontan operation. Heart (British Cardiac Society), 92(4), 511–514. https://doi.org/10.1136/hrt.2005.070243 .
doi: 10.1136/hrt.2005.070243
Ovroutski, S., Ewert, P., Alexi-Meskishvili, V., Hölscher, K., Miera, O., Peters, B., et al. (2009). Absence of pulmonary artery growth after Fontan operation and its possible impact on late outcome. Annals of Thoracic Surgery, 87(3), 826–831. https://doi.org/10.1016/j.athoracsur.2008.10.075 .
doi: 10.1016/j.athoracsur.2008.10.075
Buheitel, G., Hofbeck, M., Tenbrink, U., Leipold, G., von der Emde, J., & Singer, H. (1997). Changes in pulmonary artery size before and after total cavopulmonary connection. Heart (British Cardiac Society), 78(5), 488–492.
Restrepo, M., Mirabella, L., Tang, E., Haggerty, C. M., Khiabani, R. H., Fynn-Thompson, F., et al. (2014). Fontan pathway growth: a quantitative evaluation of lateral tunnel and extracardiac cavopulmonary connections using serial cardiac magnetic resonance. Annals of Thoracic Surgery, 97(3), 916–922. https://doi.org/10.1016/j.athoracsur.2013.11.015 .
doi: 10.1016/j.athoracsur.2013.11.015
Robbers-Visser, D., Helderman, F., Strengers, J. L., van Osch-Gevers, L., Kapusta, L., Pattynama, P. M., et al. (2008). Pulmonary artery size and function after Fontan operation at a young age. Journal of magnetic resonance imaging : JMRI, 28(5), 1101–1107. https://doi.org/10.1002/jmri.21544 .
doi: 10.1002/jmri.21544
pubmed: 18972351
Bossers, S. S. M., Cibis, M., Kapusta, L., Potters, W. V., Snoeren, M. M., Wentzel, J. J., et al. (2016). Long-term serial follow-up of pulmonary artery size and wall shear stress in Fontan patients. Pediatric Cardiology. https://doi.org/10.1007/s00246-015-1326-y .
Nakata, S., Imai, Y., Takanashi, Y., Kurosawa, H., Tezuka, K., Nakazawa, M., et al. (1984). A new method for the quantitative standardization of cross-sectional areas of the pulmonary arteries in congenital heart diseases with decreased pulmonary blood flow, The Journal of thoracic and cardiovascular surgery., 88(4), 610–619 Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/6482493 . Accessed 10 Sept 2019.
R Core Team. (2018). R: a language and environment for statistical computing. Vienna, Austria. Retrieved from https://www.r-project.org/ . Accessed 10 Sept 2019.
Muggeo, V. M. R. (2008). Segmented: an R package to fit regression models with broken-line relationships. R News, 8(1), 20–25 Retrieved from https://cran.r-project.org/doc/Rnews/ . Accessed 10 Sept 2019.
Muggeo, V. M. R. (2003). Estimating regression models with unknown break-points. Statistics in Medicine, 22, 3055–3071.
doi: 10.1002/sim.1545
Restrepo, M., Tang, E., Haggerty, C. M., Khiabani, R. H., Mirabella, L., Bethel, J., et al. (2015). Energetic implications of vessel growth and flow changes over time in Fontan patients. Annals of Thoracic Surgery, 99(1), 163–170. https://doi.org/10.1016/j.athoracsur.2014.08.046 .
doi: 10.1016/j.athoracsur.2014.08.046
Kansy, A., Brzezińska-Rajszys, G., Zubrzycka, M., Mirkowicz-Małek, M., Maruszewski, P., Manowska, M., & Maruszewski, B. (2013). Pulmonary artery growth in univentricular physiology patients. Kardiologia Polska, 71(6), 581–587. https://doi.org/10.5603/KP.2013.0121 .
doi: 10.5603/KP.2013.0121
pubmed: 23797430
Borowski, A., Reinhardt, H., Schickendantz, S., & Korb, H. (1998). Pulmonary artery growth after systemic-to-pulmonary shunt in children with a univentricular heart and a hypoplastic pulmonary artery bed. Implications for Fontan surgery. Japanese Heart Journal, 39(5), 671–680. https://doi.org/10.1016/j.athoracsur.2004.05.055 .
doi: 10.1016/j.athoracsur.2004.05.055
pubmed: 9925998
Reddy, V. M., McElhinney, D. B., Moore, P., Petrossian, E., & Hanley, F. L. (1996). Pulmonary artery growth after bidirectional cavopulmonary shunt: is there a cause for concern? The Journal of Thoracic and Cardiovascular Surgery, 112(5), 1180–1190; discussion 1190-1192. https://doi.org/10.1016/S0022-5223(96)70131-9 .
doi: 10.1016/S0022-5223(96)70131-9
pubmed: 8911314
Knott-Craig, C. J., Julsrud, P. R., Schaff, H. V., Puga, F. J., & Danielson, G. K. (1993). Pulmonary artery size and clinical outcome after the modified Fontan operation. The Annals of Thoracic Surgery, 55(3), 646–651. https://doi.org/10.1016/0003-4975(93)90268-M .
doi: 10.1016/0003-4975(93)90268-M
pubmed: 8452427
Lehner, A., Schuh, A., Herrmann, F. E. M., Riester, M., Pallivathukal, S., Dalla-Pozza, R., et al. (2014). Influence of pulmonary artery size on early outcome after the Fontan operation. Annals of Thoracic Surgery, 97(4), 1387–1393. https://doi.org/10.1016/j.athoracsur.2013.11.068 .
doi: 10.1016/j.athoracsur.2013.11.068
Adachi, I., Yagihara, T., Kagisaki, K., Hagino, I., Ishizaka, T., Kobayashi, J., et al. (2007). Preoperative small pulmonary artery did not affect the midterm results of Fontan operation. European Journal of Cardio-Thoracic Surgery, 32(1), 156–162. https://doi.org/10.1016/j.ejcts.2007.03.024 .
doi: 10.1016/j.ejcts.2007.03.024
pubmed: 17513120
Senzaki, H., Isoda, T., Ishizawa, A., & Hishi, T. (1994). Reconsideration of criteria for the Fontan operation. Influence of pulmonary artery size on postoperative hemodynamics of the Fontan operation. Circulation, 89(3), 1196–1202. https://doi.org/10.1161/01.CIR.89.3.1196 .
doi: 10.1161/01.CIR.89.3.1196
pubmed: 8124807
Baek, J. S., Bae, E. J., Kim, G. B., Kim, W. H., Lee, J. R., Kim, Y. J., et al. (2011). Pulmonary artery size and late functional outcome after Fontan operation. Annals of Thoracic Surgery, 91(4), 1240–1246. https://doi.org/10.1016/j.athoracsur.2010.12.002 .
doi: 10.1016/j.athoracsur.2010.12.002
Wagner, M., Nguyen, K.-L., Khan, S., Mirsadraee, S., Satou, G. M., Aboulhosn, J., & Finn, J. P. (2012). Contrast-enhanced MR angiography of cavopulmonary connections in adult patients with congenital heart disease. AJR. American Journal of Roentgenology, 199(5), W565–W574. https://doi.org/10.2214/AJR.11.7503 .
doi: 10.2214/AJR.11.7503
pubmed: 23096200