Analysis of Graft Failure After Primary Penetrating Keratoplasty in Children With Peters Anomaly.
Anterior Eye Segment
/ abnormalities
Child, Preschool
Cornea
/ pathology
Corneal Opacity
/ diagnosis
Eye Abnormalities
/ diagnosis
Female
Follow-Up Studies
Graft Rejection
/ diagnosis
Graft Survival
Humans
Infant
Keratoplasty, Penetrating
/ adverse effects
Male
Retrospective Studies
Risk Factors
Visual Acuity
Journal
Cornea
ISSN: 1536-4798
Titre abrégé: Cornea
Pays: United States
ID NLM: 8216186
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
pubmed:
7
4
2020
medline:
26
5
2021
entrez:
7
4
2020
Statut:
ppublish
Résumé
To investigate the causes of graft failure and risk factors associated with total graft opacity after primary penetrating keratoplasty (PK) in children with Peters anomaly (PA). In this retrospective study, patients with PA (younger than 5 years) who received primary PK in Beijing Tongren Hospital were reviewed. The follow-up period was a minimum of 6 months. A modified PA classification system was used, and all failed grafts were categorized into partial and total opacity groups. Patient demographics, PA classification, operation details, degree of graft opacity, and causes of graft failure were recorded. Of the 165 eyes, 54 eyes (32.7%) demonstrated graft failure along with various degrees of graft opacity. Approximately half of the grafts applied failed within 6 months postoperatively. The partial and total opacity groups did not demonstrate any significant differences regarding diagnosis distribution. Irreversible immune rejection accounted for 61.1% of all graft failures; furthermore, it had a significantly higher proportion in the partial opacity group than in the total opacity group (71.0% and 47.8%, respectively; P = 0.058). The degree of graft opacity was significantly associated with patient age at surgery (P = 0.002), preoperative corneal vascularization (P = 0.009), and iris defects (P = 0.001). However, administration of intensive topical corticosteroids could reduce the risk of total opacity in the rejected grafts. Irreversible immune rejection is the most common cause of graft failure after primary PK in pediatric patients with PA. The degree of graft opacity is closely related to patient age at surgery, preoperative corneal vascularization, and iris defects.
Identifiants
pubmed: 32251169
doi: 10.1097/ICO.0000000000002331
pii: 00003226-202008000-00006
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
961-967Références
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