Interleukin-17A/F1 Deficiency Reduces Antimicrobial Gene Expression and Contributes to Microbiome Alterations in Intestines of Japanese medaka (
Japanese medaka
Oryzias latipes
genome editing
interleukin-17A/F1
metagenomics
teleosts
transcriptome analysis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
18
11
2019
accepted:
25
02
2020
entrez:
8
4
2020
pubmed:
8
4
2020
medline:
24
3
2021
Statut:
epublish
Résumé
In mammals, interleukin (IL)-17A and F are hallmark inflammatory cytokines that play key roles in protection against infection and intestinal mucosal immunity. In the gastrointestinal tract (GI), the induction of antimicrobial peptide (AMP) production via Paneth cells is a fundamental role of IL-17A and F in maintaining homeostasis of the GI microbiome and health. Although mammalian IL-17A and F homologs (referred to as IL-17A/F1-3) have been identified in several fish species, their function in the intestine is poorly understood. Additionally, the fish intestine lacks Paneth cells, and its GI structure is very different from that of mammals. Therefore, the GI microbiome modulatory mechanism via IL-17A/F genes has not been fully elucidated. In this study, Japanese medaka (
Identifiants
pubmed: 32256492
doi: 10.3389/fimmu.2020.00425
pmc: PMC7092794
doi:
Substances chimiques
Fish Proteins
0
Interleukin-17
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
425Informations de copyright
Copyright © 2020 Okamura, Morimoto, Ikeda, Mizusawa, Watabe, Miyanishi, Saeki, Takeyama, Aoki, Kinoshita, Kono, Sakai and Hikima.
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