Female AhR Knockout Mice Develop a Minor Renal Insufficiency in an Adenine-Diet Model of Chronic Kidney Disease.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
03 Apr 2020
Historique:
received: 05 03 2020
revised: 31 03 2020
accepted: 01 04 2020
entrez: 9 4 2020
pubmed: 9 4 2020
medline: 14 1 2021
Statut: epublish

Résumé

Cardiovascular complications observed in chronic kidney disease (CKD) are associated with aryl hydrocarbon receptor (AhR) activation by tryptophan-derived uremic toxins-mainly indoxyl sulfate (IS). AhR is a ligand-activated transcription factor originally characterized as a receptor of xenobiotics involved in detoxification. The aim of this study was to determine the role of AhR in a CKD mouse model based on an adenine diet. Wild-type (WT) and AhR

Identifiants

pubmed: 32260098
pii: ijms21072483
doi: 10.3390/ijms21072483
pmc: PMC7177716
pii:
doi:

Substances chimiques

Ahr protein, mouse 0
Basic Helix-Loop-Helix Transcription Factors 0
Receptors, Aryl Hydrocarbon 0
Xanthine Dehydrogenase EC 1.17.1.4
Adenine JAC85A2161

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Camélia Makhloufi (C)

C2VN, Aix Marseille University, INSERM 1263, INRAe, 13005 Marseille, France.

Fanny Nicolas (F)

C2VN, Aix Marseille University, INSERM 1263, INRAe, 13005 Marseille, France.

Nathalie McKay (N)

C2VN, Aix Marseille University, INSERM 1263, INRAe, 13005 Marseille, France.

Samantha Fernandez (S)

CERIMED, Aix-Marseille University, 13005 Marseille, France.

Guillaume Hache (G)

C2VN, Aix Marseille University, INSERM 1263, INRAe, 13005 Marseille, France.
CERIMED, Aix-Marseille University, 13005 Marseille, France.
APHM, Service de Pharmacie, 13005 Marseille, France.

Philippe Garrigue (P)

C2VN, Aix Marseille University, INSERM 1263, INRAe, 13005 Marseille, France.
CERIMED, Aix-Marseille University, 13005 Marseille, France.
APHM, Service de Radiopharmacie, 13005 Marseille, France.

Philippe Brunet (P)

C2VN, Aix Marseille University, INSERM 1263, INRAe, 13005 Marseille, France.
APHM, Centre de néphrologie et transplantation rénale, 13005 Marseille, France.

Benjamin Guillet (B)

C2VN, Aix Marseille University, INSERM 1263, INRAe, 13005 Marseille, France.
CERIMED, Aix-Marseille University, 13005 Marseille, France.
APHM, Service de Radiopharmacie, 13005 Marseille, France.

Stéphane Burtey (S)

C2VN, Aix Marseille University, INSERM 1263, INRAe, 13005 Marseille, France.
APHM, Centre de néphrologie et transplantation rénale, 13005 Marseille, France.

Stéphane Poitevin (S)

C2VN, Aix Marseille University, INSERM 1263, INRAe, 13005 Marseille, France.

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Classifications MeSH